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首页> 美国卫生研究院文献>Nutrients >Influence of Ultra-Processed Foods Consumption on Redox Status and Inflammatory Signaling in Young Celiac Patients
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Influence of Ultra-Processed Foods Consumption on Redox Status and Inflammatory Signaling in Young Celiac Patients

机译：超加工食品消费对年轻乳腺患者氧化还原状态和炎症信号的影响

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The current study was designed to assess the influence of consumption of ultra-processed (UPF) on oxidative/antioxidant balance and evoked inflammatory signaling in young patients with celiac disease (CD). The study included 85 children. The celiac group (n = 53) included children with CD with a long (>18 months, n = 17) or recent (<18 months, n = 36) adherence to a gluten-free diet (GFD). The control group (n = 32) included healthy children with a significantly lower consumption of UPF compared to the CD group, both expressed as kcal/day (p = 0.043) and as percentage of daily energy intake (p = 0.023). Among children with CD, the group with the lowest consumption of UPF (below the 50% of daily energy intake) had a greater Mediterranean diet (MD) adherence and higher moderate physical activity levels. In addition, CD children with the lowest consumption of UPF had healthier redox (lower soluble superoxide dismutase-1 and 15-F2t-isoprostanes) and inflammatory profiles (lower macrophage inflammatory protein-1α) compared to the group with the highest consumption of UPF (all, p < 0.05) regardless of the time on a GFD. These findings highlight the importance of a correct monitoring of the GFD. An unbalanced GFD with high consumption of UPF and an unhealthy pattern with less physical activity and worse adherence to MD results in a worse inflammatory profile, which could act as a parallel pathway that could have important consequences on the pathophysiology of the disease.
机译：目前的研究旨在评估超加工（UPF）消耗对氧化/抗氧化剂平衡的影响，并在腹菌疾病（CD）中的年轻患者中诱发炎症信号传导。该研究包括85名儿童。腹腔组（n = 53）包括镉的儿童，长（> 18个月，n = 17）或近期（<18个月，n = 36）粘附到无麸质饮食（GFD）。与CD组相比，对照组（n = 32）包括健康儿童，与CD组相比，均表达为kcal /天（p = 0.043），作为日常能量摄入量的百分比（p = 0.023）。在CD的儿童中，具有最低消耗UPF的组（低于每日能量摄入量的50％）具有更大的地中海饮食（MD）依从性和更高的中度身体活动水平。此外，与具有最高耗电量的组（以下）的群体（所有，P <0.05）无论GFD上的时间如何。这些发现突出了对GFD正确监测的重要性。一种不平衡的GFD，具有高耗材的UPF和不健康的模式，具有较少的身体活动和对MD的依赖性依赖于MD的依赖性导致更差的炎症性剖面，这可以充当平行途径，这可能对疾病的病理生理学具有重要影响。

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