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NNT-AS1 modulates prostate cancer cell proliferation apoptosis and migration through miR-496/DDIT4 axis

机译：NNT-AS1通过miR-496 / ddit4轴调节前列腺癌细胞增殖细胞凋亡和迁移

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NNT-AS1 knockdown inhibited PCa cell viability, proliferation, migration and promoted apoptosis. a NNT-AS1 expression was examined using RT-qPCR in PCa cells. b NNT-AS1 expression was detected by RT-qPCR in PCa cells transfected with shRNAs targeting NNT-AS1. c CCK-8 assay indicated cell viability when NNT-AS1 was down-regulated in VCaP and PC3 cells. d, e EdU and colony formation assays measured cell proliferation in VCaP and PC3 cells with or without NNT-AS1 inhibition. f, g Flow cytometry analysis and JC-1 assay examined the apoptosis rate of VCaP and PC3 cells with or without NNT-AS1 silence. h Wound healing assay displayed the migration capacity of VCaP and PC3 cells with silenced NNT-AS1 or not. *p < 0.05, **p < 0.01

机译：NNT-AS1敲低抑制PCA细胞活力，增殖，迁移和促进的凋亡。使用PCA细胞中使用RT-QPCR检查NNT-AS1表达。通过用靶向NNT-AS1的SHRNA转染的PCA细胞中的RT-QPCR检测到BNT-AS1表达。 C CCK-8测定指示当NNT-AS1在VCAP和PC3细胞中下调时的细胞活力。 D，E EDU和菌落形成测定在VCAP和PC3细胞中测量的细胞增殖，或没有NNT-AS1抑制。 F，G流式细胞术分析和JC-1测定检测了VCAP和PC3细胞的凋亡率和没有NNT-AS1沉默。 H缠绕愈合测定显示VCAP和PC3细胞的迁移容量，致密的NNT-AS1。 * P <0.05，** P <0.01

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期刊名称 Cancer Cell International
作者
Changlei Yao; Xianghua Cheng; Xiuquan Guo; Xulou Lu; Fan Bu; Yanfen Xu;
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作者单位

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年(卷),期 2020(-1),-1
年度 2020
页码 -1
总页数 11
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词

机译：前列腺癌;NNT-AS1;MIR-496;DDIT4;

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1. Long non-coding RNA TOB1-AS1 modulates cell proliferation, apoptosis, migration and invasion through miR-23a/NEU1 axis via Wnt/b-catenin pathway in gastric cancer [J] . K. Jiang, X.-H. Zhi, Y.-Y. Ma, European review for medical and pharmacological sciences. . 2019,第22期

机译：长期非编码RNA TOB1-AS1通过胃癌中的WNT / B-Catenin途径调节细胞增殖，细胞凋亡，迁移和侵袭，通过Wnt / B-catenin途径
2. TAZ is overexpressed in prostate cancers and regulates the proliferation, migration and apoptosis of prostate cancer PC3 cells [J] . Lin Mengyuan, Bu Chaozhi, He Qingwen, Oncology reports . 2020,第2期

机译：TAZ在前列腺癌中过表达，并调节前列腺癌PC3细胞的增殖，迁移和凋亡
3. Novel C-4 Heteroaryl 13-cis-Retinamide Mnk/AR Degrading Agents Inhibit Cell Proliferation and Migration and Induce Apoptosis in Human Breast and Prostate Cancer Cells and Suppress Growth of MDA-MB-231 Human Breast and CWR22Rv1 Human Prostate Tumor Xenografts in Mice [J] . Mbatia Hannah W., Ramalingam Senthilmurugan, Ramamurthy Vidya P., Journal of Medicinal Chemistry . 2015,第4期

机译：新型C-4杂芳基13-顺式视黄酰胺Mnk / AR降解剂抑制人乳腺癌和前列腺癌细胞的增殖和迁移并诱导其凋亡，并抑制MDA-MB-231人乳腺癌和CWR22Rv1人前列腺肿瘤异种移植物的生长。
4. Study on the Effect of Herba Sarcandrae on Proliferation and Apoptosis of Prostate Cancer DU -145 Cell [C] . Xiuxia Wang International Conference on Environment, Materials, Chemistry and Power Electronics . 2016

机译：Herba Sarcandrae对前列腺癌细胞增殖和凋亡的影响研究
5. Effect of androgen and natural compounds on proliferation of androgen-independent LNCaP human prostate cancer cells and prostate cancer progression. [D] . Chuu, Chih-pin. 2005

机译：雄激素和天然化合物对雄激素非依赖性LNCaP人前列腺癌细胞增殖和前列腺癌进展的影响。
6. Long non-coding RNA PRNCR1 modulates non-small cell lung cancer cell proliferation apoptosis migration invasion and EMT through PRNCR1/miR-126-5p/MTDH axis [O] . Ran Guo, Tongchen Hu, Yanheng Liu, -1

机译：长期非编码RNA PRNCR1通过PRNCR1 / MIR-126-5P / MTDH轴调节非小细胞肺癌细胞增殖细胞凋亡迁移侵袭和EMT
7. NNT-AS1 modulates prostate cancer cell proliferation, apoptosis and migration through miR-496/DDIT4 axis [O] . Changlei Yao, Xianghua Cheng, Xiuquan Guo, 2020

机译：NNT-AS1通过miR-496 / ddit4轴调节前列腺癌细胞增殖，细胞凋亡和迁移

NNT-AS1 modulates prostate cancer cell proliferation apoptosis and migration through miR-496/DDIT4 axis

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