The Caspase-8 Homolog Dredd Cleaves Imd and Relish but Is Not Inhibited by p35

机译：Caspase-8同源物疏通了Imd和美味但不受p35的抑制

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In Drosophila, the Imd pathway is activated by diaminopimelic acid-type peptidoglycan and triggers the humoral innate immune response, including the robust induction of antimicrobial peptide gene expression. Imd and Relish, two essential components of this pathway, are both endoproteolytically cleaved upon immune stimulation. Genetic analyses have shown that these cleavage events are dependent on the caspase-8 like Dredd, suggesting that Imd and Relish are direct substrates of Dredd. Among the seven Drosophila caspases, we find that Dredd uniquely promotes Imd and Relish processing, and purified recombinant Dredd cleaves Imd and Relish in vitro. In addition, interdomain cleavage of Dredd is not required for Imd or Relish processing and is not observed during immune stimulation. Baculovirus p35, a suicide substrate of executioner caspases, is not cleaved by purified Dredd in vitro. Consistent with this biochemistry but contrary to earlier reports, p35 does not interfere with Imd signaling in S2* cells or in vivo.

机译：在果蝇中，Imd途径被二氨基庚二酸型肽聚糖激活，并触发体液先天免疫应答，包括强烈诱导抗菌肽基因表达。 Imd和Relish是该途径的两个基本组成部分，均在免疫刺激后被内蛋白水解切割。遗传分析表明，这些裂解事件像Dredd一样依赖于caspase-8，这表明Imd和Relish是Dredd的直接底物。在七个果蝇胱天蛋白酶中，我们发现Dredd独特地促进Imd和Relish加工，并且纯化的重组Dredd在体外裂解Imd和Relish。另外，对于Imd或Relish加工，不需要Dredd的域间切割，并且在免疫刺激过程中也未观察到。杆状病毒p35的杆状病毒的自杀底物杆状病毒p35在体外不被纯化的Dredd切割。与此生物化学一致，但与早期报道相反，p35不会干扰S2 *细胞或体内的Imd信号传导。

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期刊名称 The Journal of Biological Chemistry
作者
Chan-Hee Kim; Donggi Paik; Florentina Rus; Neal Silverman;
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作者单位

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年(卷),期 2014(289),29
年度 2014
页码 20092–20101
总页数 10
原文格式 PDF
正文语种
中图分类分子生物学;
关键词
Caspase Drosophila Innate Immunity Insect Immunity NF-κB Dredd Imd p35 Relish;

机译：半胱天冬酶;果蝇;先天免疫;昆虫免疫;NF-κB;Dredd;Imd;p35;美味;

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专利

1. The Caspase-8 Homolog Dredd Cleaves Imd and Relish but Is Not Inhibited by p35 [J] . Chan-Hee Kim, Donggi Paik, Florentina Rus, The Journal of biological chemistry . 2014,第29期

机译：Caspase-8同性恋Dredd切割IMD并释放，但不受P35抑制
2. A tandem death effector domain-containing protein inhibits the IMD signaling pathway via forming amyloid-like aggregates with the caspase-8 homolog DREDD [J] . Hu Jie, Wang Xinyi, Xiao Xiaoyi, Insect Biochemistry and Molecular Biology . 2019,第期

机译：含有串联死亡效应域的蛋白质通过与Caspase-8同源物DREDD形成淀粉样蛋白状聚集体抑制IMD信号传导途径
3. Kep1 interacts genetically with dredd/caspase-8, and kep1 mutants alter the balance of dredd isoforms. [J] . Di Fruscio M, Styhler S, Wikholm E, Proceedings of the National Academy of Sciences of the United States of America . 2003,第4期

机译：Kep1与dredd / caspase-8在遗传上相互作用，而kep1突变体改变了dredd亚型的平衡。
4. A Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) Cleaves the Synthetic Fragment Peptides of Prion Protein, and That is Inhibited by the Copper Ion [C] . Aya Kojima, Yasunori Mabuchi, Rika Okihara Japanese peptide symposium . 2011

机译：膜型-1基质金属蛋白酶（MT1-MMP）切割朊病毒蛋白的合成片段肽，并被铜离子抑制
5. kep1 interacts genetically with dredd/Caspase-8 and kep1 mutants alter the balance of dredd isoforms [O] . Marco Di Fruscio, Sylvia Styhler, Eva Wikholm, 2003

机译：kep1与dredd / Caspase-8基因相互作用并且kep1突变体改变了dredd亚型的平衡。
6. The caspase-8 homolog Dredd cleaves Imd and Relish but is not inhibited by p35 [O] . Kim, Chan-Hee, Paik, Donggi, Rus, Florentina, 2014

机译：caspase-8同系物Dredd切割Imd和Relish但不被p35抑制

The Caspase-8 Homolog Dredd Cleaves Imd and Relish but Is Not Inhibited by p35

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