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首页> 美国卫生研究院文献>Journal of Bacteriology >Interspecies recombination between the penA genes of Neisseria meningitidis and commensal Neisseria species during the emergence of penicillin resistance in N. meningitidis: natural events and laboratory simulation.
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Interspecies recombination between the penA genes of Neisseria meningitidis and commensal Neisseria species during the emergence of penicillin resistance in N. meningitidis: natural events and laboratory simulation.

机译：脑膜炎奈瑟氏球菌对青霉素耐药的出现期间脑膜炎奈瑟氏球菌和共性奈瑟氏球菌的penA基因之间的种间重组：自然事件和实验室模拟。

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摘要

The penicillin-binding protein 2 genes (penA) of penicillin-resistant Neisseria meningitidis have a mosaic structure that has arisen by the introduction of regions from the penA genes of Neisseria flavescens or Neisseria cinerea. Chromosomal DNA from both N. cinerea and N. flavescens could transform a penicillin-susceptible isolate of N. meningitidis to increased resistance to penicillin. With N. flavescens DNA, transformation to resistance was accompanied by the introduction of the N. flavescens penA gene, providing a laboratory demonstration of the interspecies recombinational events that we believe underlie the development of penicillin resistance in many meningococci in nature. Surprisingly, with N. cinerea DNA, the penicillin-resistant transformants did not obtain the N. cinerea penA gene. However, the region of the penA gene derived from N. cinerea in N. meningitidis K196 contained an extra codon (Asp-345A) which was not found in any of the four N. cinerea isolates that we examined and which is known to result in a decrease in the affinity of PBP 2 in gonococci.
机译：耐青霉素的脑膜炎奈瑟氏球菌的青霉素结合蛋白2基因（penA）具有镶嵌结构，该结构是通过从黄萎病奈瑟氏菌或灰质奈瑟氏菌的penA基因引入区域而产生的。灰质猪笼草和苦参猪笼草的染色体DNA均可将对青霉素敏感的脑膜炎奈瑟菌分离株转化为对青霉素的耐药性增强。用黄萎病菌DNA，向抗病性的转化伴随着黄萎病菌penA基因的引入，提供了种间重组事件的实验室证明，我们认为这是自然界许多脑膜炎球菌对青霉素耐药性发展的基础。令人惊讶的是，对于灰质猪笼草DNA，抗青霉素的转化体未获得灰质猪笼草penA基因。然而，在脑膜炎奈瑟氏球菌K196中，源自灰霉奈瑟氏菌的penA基因区域包含一个额外的密码子（Asp-345A），该密码子在我们检查的四个灰霉奈瑟氏菌分离物中均未发现。淋球菌中PBP 2的亲和力降低。

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