S-Amlodipine: An Isomer with Difference—Time to Shift from Racemic Amlodipine

机译：S-氨氯地平：具有差异的异构体—从消旋氨氯地平转变的时间

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Calcium channel blockers are among the first-line drugs for treatment of hypertension (HTN). S-amlodipine (S-AM), an S-enantiomer of amlodipine, is available in India and in other countries like China, Korea, Russia, Ukraine, and Nepal. Being clinically researched for nearly two decades, we performed in-depth review of S-AM. This review discusses clinical evidence from total 42 studies (26 randomized controlled trials, 14 observational studies, and 2 meta-analyses) corroborating over 7400 patients treated with S-AM. Efficacy and safety of S-AM in HTN in comparison to racemic amlodipine, used as monotherapy and in combination with other antihypertensives, efficacy in angina, and pleiotropic benefits with S-AM, are discussed in this review.

机译：钙通道阻滞剂是用于治疗高血压（HTN）的一线药物。氨氯地平的S-对映体S-氨氯地平（S-AM）在印度和其他国家（如中国，韩国，俄罗斯，乌克兰和尼泊尔）有售。经过近二十年的临床研究，我们对S-AM进行了深入审查。这篇综述讨论了总共42项研究（26项随机对照试验，14项观察性研究和2项荟萃分析）的临床证据，这些证据证实了7400例接受S-AM治疗的患者。与消旋氨氯地平相比，单药治疗以及与其他降压药联合使用时，S-AM在HTN中的疗效和安全性，心绞痛的疗效以及S-AM的多效性均在本文中进行了讨论。

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期刊名称 International Journal of Hypertension
作者
Jamshed Dalal; J. C. Mohan; S. S. Iyengar; Jagdish Hiremath; Immaneni Sathyamurthy; Sandeep Bansal; Dhiman Kahali; Arup Dasbiswas;
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年(卷),期 2018(2018),-1
年度 2018
页码 8681792
总页数 14
原文格式 PDF
正文语种
中图分类心血管疾病;
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专利

1. S-Amlodipine: An Isomer with Difference—Time to Shift from Racemic Amlodipine [J] . Jamshed Dalal, J. C. Mohan, S. S. Iyengar, International Journal of Hypertension . 2018,第1期

机译：S-氨氯地平：具有差异的异构体—从消旋氨氯地平转变的时间
2. Determination of S- and R-Amlodipine in Rat Plasma using LC-MS/MS After Oral Administration of S-Amlodipine and Racemic Amlodipine [J] . Yoo Hye-Hyun, Kim Tae-Kon, Lee Bong-Yong, Mass Spectrometry Letters . 2011,第4期

机译：口服S-氨氯地平和消旋氨氯地平后，使用LC-MS / MS测定大鼠血浆中的S-和R-氨氯地平
3. Differentiation of Meso Isomers from Racemic Mixtures with the Combined Use of Chiral Shift Reagents and Two-Dimensional Heteronuclear Correlation NMR Spectroscopy [J] . P. Mark Henrichs, Charles A. Rodger, Thomas Caulfield, Magnetic Resonance in Chemistry . 1995,第11期

机译：外消旋混合物的内消旋异构体与手性转移试剂和二维异核相关核磁共振谱法的结合使用
4. An Adaptive Threshold Algorithm Combining Shifting Window Difference and Forward-Backward Difference in Real-Time R-Wave Detection [C] . She, Lihuang, Wang, Guohua, Zhang, Shi, International Congress on Image and Signal Processing;CISP '09 . 2009

机译：实时R波检测中结合移动窗口差和前后差的自适应阈值算法
5. Towards Clinical Translation of the Porphysome: Establishment of Endometrial Cancer Applications and Investigation of Metabolic Differences in Pyrolipid Isomers [D] . Philp, Lauren Anne Catherine 2018

机译：走向Porphysome的临床翻译：子宫内膜癌应用的建立和磷脂异构体代谢差异的研究
6. Predominant and Substoichiometric Isomers of the Plastid Genome Coexist within Juniperus Plants and Have Shifted Multiple Times during Cupressophyte Evolution [O] . Wenhu Guo, Felix Grewe, Amie Cobo-Clark, 2014

机译：质子体基因组的主要和亚化学计量异构体共存于Jun草植物中并且在CuCupyophyte进化过程中发生了多次移位
7. Predominant and Substoichiometric Isomers of the Plastid Genome Coexist within Juniperus Plants and Have Shifted Multiple Times during Cupressophyte Evolution [O] . Wenhu Guo, Felix Grewe, Amie Cobo-Clark, 2014

机译：葡萄球菌植物中的体积基因组共存的主要和倒数异构体并在愚蠢的演变期间多次移位
8. Time-Shift Theorems for Walsh Transforms and Solution of Difference Equations. [R] . Cheng, D. K., Liu, J. J. 1975

机译：沃尔什变换的时移定理及差分方程的解。

S-Amlodipine: An Isomer with Difference—Time to Shift from Racemic Amlodipine

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