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首页> 美国卫生研究院文献>PLoS Clinical Trials >A 90-Day Dietary Toxicity Study of Genetically Modified Rice T1C-1 Expressing Cry1C Protein in Sprague Dawley Rats
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A 90-Day Dietary Toxicity Study of Genetically Modified Rice T1C-1 Expressing Cry1C Protein in Sprague Dawley Rats

机译：转基因水稻T1C-1在Sprague Dawley大鼠中表达Cry1C蛋白的90天饮食毒性研究

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In a 90-day study, Sprague Dawley rats were fed transgenic T1C-1 rice expressing Cry1C protein and were compared with rats fed non-transgenic parental rice Minghui 63 and rats fed a basal diet. No adverse effects on animal behavior or weight gain were observed during the study. Blood samples were collected and analyzed, and standard hematological and biochemical parameters were compared. A few of these parameters were found to be significantly different, but were within the normal reference intervals for rats of this breed and age, and were thus not considered to be treatment-related. Following sacrifice, a large number of organs were weighed, and macroscopic and histopathological examinations were performed with no changes reported. The aim of this study was to use a known animal model to determine the safety of the genetically modified (GM) rice T1C-1. The results showed no adverse or toxic effects due to T1C-1 rice when tested in this 90-day study.
机译：在一项为期90天的研究中，给Sprague Dawley大鼠喂食表达Cry1C蛋白的转基因T1C-1水稻，并与喂食非转基因亲本水稻Minghui 63的大鼠和喂食基础饮食的大鼠进行比较。在研究过程中未观察到对动物行为或体重增加的不利影响。收集血样并进行分析，并比较标准的血液学和生化参数。这些参数中的一些参数发现有显着差异，但在该品种和年龄的大鼠的正常参考间隔内，因此不被视为与治疗相关。处死后，称重大量器官，并进行宏观和组织病理学检查，无变化报道。这项研究的目的是使用一种已知的动物模型来确定转基因水稻T1C-1的安全性。在这项为期90天的研究中进行测试时，结果显示没有因T1C-1大米引起的不利或毒性​​作用。

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