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首页> 外文期刊>Acta Neuropathologica >Genetic evidence of the neoplastic nature of gemistocytes in astrocytomas
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Genetic evidence of the neoplastic nature of gemistocytes in astrocytomas

机译：星形细胞瘤中双核细胞的肿瘤性质的遗传证据

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摘要

Gemistocytic astrocytoma is characterized by a predominance of large astrocytes with plump processes and massive accumulation of glial fibrillary acidic protein (gemistocytes). This histological variant of low-grade diffuse astrocytoma (WHO grade II) is prone to more rapid progression to anaplastic astrocytoma and glioblastoma than the ordinary fibrillary astrocytoma. The biological basis of this unfavorable prognosis is unclear, since gemistocytes themselves have low proliferative activity, even if present in anaplastic astrocytomas or glioblastomas. This has raised the question of whether gemistocytes are neoplastic cells or dysplastic reactive astrocytes. In this study, gemistocytes and non-gemistocytic neoplastic cells were separated by laser-assisted microdissection from six gemistocytic astrocytomas carrying TP53 mutations. In all cases, identical TP53 mutations were identified in both cell types, indicating that gemistocytes are indeed neoplastic cells. Their lack of proliferative activity may indicate terminal differentiation.
机译：粒细胞星形细胞瘤的特征是大量星形胶质细胞具有丰满的过程和神经胶质原纤维酸性蛋白（双核细胞）的大量积累。低级弥漫性星形细胞瘤的这种组织学变体（WHO II级）比普通纤维状星形细胞瘤更容易发展为间变性星形细胞瘤和胶质母细胞瘤。尚不清楚这种不良预后的生物学基础，因为即使存在于间变性星形细胞瘤或成胶质细胞瘤中，双核细胞本身的增殖活性也很低。这就提出了一个问题，即双核细胞是赘生性细胞还是发育不良的反应性星形胶质细胞。在这项研究中，通过激光辅助显微切割从六个携带TP53突变的双核星形细胞瘤中分离出双核细胞和非双核细胞瘤细胞。在所有情况下，在两种细胞类型中均鉴定出相同的TP53突变，表明双核细胞确实是赘生性细胞。它们缺乏增殖活性可能表明终末分化。

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