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首页> 外文期刊>Advanced Functional Materials >Nanostructured Polymer Brushes by UV-Assisted Imprint ithography and Surface-Initiated Polymerization for Biological Functions
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Nanostructured Polymer Brushes by UV-Assisted Imprint ithography and Surface-Initiated Polymerization for Biological Functions

机译：紫外线辅助压印光刻和表面引发的生物功能纳米结构聚合物刷

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摘要

Functional polymer brush nanostructures are obtained by combining step-and-flash imprint lithography (SFIL) with controlled, surface-initiated polymerization (CSIP). Patterning is achieved at length scales such that the smallest elements have dimensions in the sub-100 nm range. The patterns exhibit different shapes, including lines and pillars, over large surface areas. The platforms obtained are used to selectively immobilize functional biomacromolecules. Acrylate-based polymer resist films patterned by SFIL are first used for the selective immobilization of ATRP silane-based initiators, which are coupled to unprotected domains of silicon substrates. These selectively deposited initiators are then utilized in the controlled radical SIP of polyethylene glycol)methacrylates (PEGMA). Nanostructured brush surfaces are then obtained by removal of the resist material. The areas previously protected by the SFIL resist are passivated by inert, PEC-based silane monolayers following resist removal. PECMA brush nanostructures are finally functionalized with biotin units in order to provide selective attachment points for streptavidin proteins. Atomic force microscopy and fluorescence spectroscopy confirm the successful immobilization of streptavidin molecules on the polymer grafts. Finally, it is demontrated that this fabrication method allows the immobilization of a few tens of protein chains attached selectively to brush nanostructures, which are surrounded by nonfouling PEC-functionalized areas.
机译：功能性聚合物刷纳米结构是通过结合分步闪光印刷光刻（SFIL）和受控的表面引发的聚合（CSIP）获得的。在长度尺度上实现图案化，使得最小的元件的尺寸在100 nm以下。图案在较大的表面积上显示出不同的形状，包括线条和柱子。获得的平台用于选择性固定功能性生物大分子。首先将通过SFIL图案化的丙烯酸酯基聚合物抗蚀剂膜用于选择性固定ATRP硅烷基引发剂，该引发剂与硅基板的未保护区域偶联。然后将这些选择性沉积的引发剂用于聚乙二醇）甲基丙烯酸酯（PEGMA）的受控自由基SIP中。然后通过去除抗蚀剂材料获得纳米结构的刷子表面。去除抗蚀剂后，先前由SFIL抗蚀剂保护的区域被惰性，基于PEC的硅烷单层钝化。 PECMA刷纳米结构最终被生物素单元功能化，以提供链霉亲和素蛋白的选择性附着点。原子显微镜和荧光光谱证实链霉亲和素分子已成功固定在聚合物接枝上。最终，被破坏的是这种制造方法允许固定选择性附着在刷子纳米结构上的数十个蛋白质链，而刷子纳米结构被无污垢的PEC官能化区域所包围。

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  • 来源
    《Advanced Functional Materials》 |2011年第11期|p.2088-2095|共8页
  • 作者

    Edmondo M. Benetti; Canet Acikgoz; Xiaofeng Sui; Boris Vratzov; Mark A. Hempenius; Jurriaan Huskens; G.Julius Vancso;

  • 作者单位

    ETH Zurich, Dept. of Materials Laboratory for Surface Science and Technology Wolfgang Pauli Strasse 10, HCI G543, 8093 Zurich, Switzerland;

    Materials Science and Technology of PolymersMESA+ Institute for Nanotechnology University of Twente P.O. Box 21 7, 7500 AE Enschede, The Netherlands;

    Materials Science and Technology of PolymersMESA+ Institute for Nanotechnology University of Twente P.O. Box 21 7, 7500 AE Enschede, The Netherlands;

    Dr. B. Vratzov NT&D-Nanotechnology and Devices Wirichsbongardstr. 24, 52062 Aachen, Germany;

    Materials Science and Technology of PolymersMESA+ Institute for Nanotechnology University of Twente P.O. Box 21 7, 7500 AE Enschede, The Netherlands;

    Prof. J. Huskens Molecular Nanofabrication Croup MESA+ Institute for Nanotechnology University of Twente P.O. Box 21 7, 7500 AE Enschede, The Netherlands;

    Materials Science and Technology of Polymers MESA+ Institute for Nanotechnology University of Twente P.O. Box 217, 7500 AE Enschede, The Netherlands;

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