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Temporal variation in the acute effects of air pollution on blood pressure measured at admission to labor/delivery

机译：入院/分娩时空气污染对血压的急性影响的时间变化

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摘要

Same day or recent air pollution exposure increases blood pressure in pregnant women. Temporal blood pressure variation associated with hourly air pollution is unstudied. We randomly selected 500 women (249 normotensive, 191 with hypertensive disorders, and 60 with chronic hypertension) with singleton pregnancies and blood pressure measured at labor/delivery admission from a large cohort, the Consortium on Safe Labor. Community multiscale air quality models estimated hourly air pollutant exposures for the admission hour (lag 0) and for the 24 h preceding labor/delivery admission (lags 1–24). Linear regression estimated the effect of 10 % increase in pollutants on blood pressure at each time point, adjusting for maternal characteristics, labor type, and time of day. Women with chronic hypertension had higher systolic blood pressure with exposure to particulate matter <10 μm (by 1.0–1.3 mmHg at 0–4 h), sulfur dioxide (by 0.7–0.9 mmHg at 0–3, 16–20, and 22–23 h) and with some air toxics. Diastolic blood pressure was higher in normotensive women with ozone exposure (by 0.1–0.4 mmHg at 0–1 and 23–24 h). Similar effects for systolic blood pressure were seen among women with hypertensive disorders (by 0.6 mmHg at 19–20 h), but most pollutants were associated with lower blood pressure in these women. Substantial variation in the impact of hourly air pollutant measures on blood pressure was observed during the day prior to labor/delivery admission, both by mothers’ hypertensive status and by the lag time prior to BP measurement. Effects were largest near admission (lags 0–4) and among women with chronic hypertension.
机译：当天或近期暴露在空气污染中会增加孕妇的血压。与每小时的空气污染相关的时间性血压变化尚未得到研究。我们从一个大型队列“安全劳动联盟”中随机抽取了500名妇女（单身妊娠和血压），这些妇女在分娩/分娩时测量了单胎妊娠和血压，其中249名血压正常，191名高血压疾病，60名慢性高血压。社区多尺度空气质量模型估计了入场小时（滞后0）和之前的24小时人工/交付入场（滞后1-24）的每小时空气污染物暴露量。线性回归估计了每个时间点污染物增加10％对血压的影响，并根据孕产妇特征，分娩类型和一天中的时间进行了调整。患有慢性高血压的妇女的收缩压较高，其颗粒物质<10μm（在0–4 h时降低1.0–1.3 mmHg），二氧化硫（在0–3、16–20和22–20时升高0.7–0.9 mmHg）。 23 h）并带有一些空气中的毒物。血压正常的臭氧暴露妇女的舒张压较高（在0–1和23–24 h时舒张压为0.1–0.4 mmHg）。在患有高血压疾病的女性中，收缩压的影响相似（在19-20h时降低0.6mmHg），但这些女性的大多数污染物与血压降低有关。在准许分娩/分娩前一天，每小时的空气污染物测量值对血压的影响有很大的变化，这既有母亲的高血压状态，也有血压测量前的滞后时间。入院时的影响最大（滞后0–4），在患有慢性高血压的妇女中影响最大。

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  • 来源
    《Air quality, atmosphere & health》 |2015年第1期|13-28|共16页
  • 作者

    Tuija M?nnist?; Pauline Mendola; Danping Liu; Kira Leishear; Qi Ying; Rajeshwari Sundaram;

  • 作者单位

    1.Epidemiology Branch Division of Intramural Population Health Research Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health 6100 Executive Blvd 7B05 Rockville MD 20852 USA;

    1.Epidemiology Branch Division of Intramural Population Health Research Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health 6100 Executive Blvd 7B05 Rockville MD 20852 USA;

    2.Biostatistics and Bioinformatics Branch Division of Intramural Population Health Research Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health 6100 Executive Blvd 7B05 Rockville MD 20852 USA;

    3.Division of Intramural Population Health Research Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health 6100 Executive Blvd 7B05 Rockville MD 20852 USA;

    4.Zachry Department of Civil Engineering Texas AM University 3136 TAMU College Station Texas TX 77843-3136 USA;

    2.Biostatistics and Bioinformatics Branch Division of Intramural Population Health Research Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health 6100 Executive Blvd 7B05 Rockville MD 20852 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Epidemiology; Blood pressure; Pregnancy; Air pollution; Temporal variation;

    机译：流行病学;血压;妊娠;空气污染;时间变化;

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