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首页> 外文期刊>Applied Surface Science >The Application With Protocatechualdehyde To Improve Anticoagulant Activity And Cell Affinity Of Silk Fibroin
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The Application With Protocatechualdehyde To Improve Anticoagulant Activity And Cell Affinity Of Silk Fibroin

机译：原儿茶醛在提高丝素蛋白抗凝活性和细胞亲和力中的应用

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Protocatechualdehyde (PCA) is one of the effective ingredients extracted from Danshen (Radix Salviae Miltiorrhizae) and was employed to modify the silk fibroin (SF) by graft polymerization and surface adsorption. The surface composition of modified SF was characterized by attenuated total reflectance Fourier-transform infrared (ATR-FTIR), X-ray photoelectron spectroscopy (XPS), and UV spectro-photometer. The anticoagulant activity of modified SF was assessed by in vitro coagulation test and platelet adhesion measurement. The endothelial cell affinity was evaluated by a parallel plate flow chamber. The test results indicated that with the introduction of PCA into SF, the anticoagulant activity has been improved obviously. And the SF surface composition altered by PCA, but did not disturb its β-sheet conformation. Moreover, the adsorbed PCA on SF surface can enhance the endothelial cell affinity.
机译：原儿茶醛（PCA）是从丹参（Radix Salviae Miltiorrhizae）中提取的有效成分之一，并用于通过接枝聚合和表面吸附来修饰丝素蛋白（SF）。通过衰减的全反射傅立叶变换红外光谱仪（ATR-FTIR），X射线光电子能谱仪（XPS）和紫外分光光度计来表征改性SF的表面成分。通过体外凝血试验和血小板粘附性测量评估改性SF的抗凝活性。通过平行板流动室评估内皮细胞亲和力。试验结果表明，将PCA引入SF后，抗凝活性明显提高。 PCA改变了SF的表面组成，但不影响其β-折叠构象。此外，SF表面上吸附的PCA可以增强内皮细胞亲和力。

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