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首页> 外文期刊>World Journal of Gastroenterology >Gene therapy for gastric cancer: is it promising?
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Gene therapy for gastric cancer: is it promising?

机译:胃癌的基因治疗:有希望吗?

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摘要

Gastric cancer is one of the most common tumors worldwide. The therapeutic outcome of conventional therapies is inefficient. Thus, new therapeutic strategies are urgently needed. Gene therapy is a promising molecular alternative in the treatment of gastric cancer, including the replacement of defective tumor suppressor genes, the inactivation of oncogenes, the introduction of suicide genes, genetic immunotherapy, anti-angiogenetic gene therapy, and virotherapy. Improved molecular biological techniques and a better understanding of gastric carcinogenesis have allowed us to validate a variety of genes as molecular targets for gene therapy. This review provides an update of the new developments in cancer gene therapy, new principles, techniques, strategies and vector systems, and shows how they may be applied in the treatment of gastric cancer.
机译:胃癌是全世界最常见的肿瘤之一。常规疗法的治疗结果是无效的。因此,迫切需要新的治疗策略。基因疗法是治疗胃癌的一种有前途的分子替代方法,包括替换有缺陷的抑癌基因,使癌基因失活,引入自杀基因,遗传免疫疗法,抗血管生成基因疗法和病毒疗法。改良的分子生物学技术和对胃癌发生的更好理解使我们能够验证多种基因作为基因治疗的分子靶标。这篇综述提供了癌症基因治疗的新进展,新原理,新技术,新策略和新载体系统的更新,并展示了它们如何应用于胃癌的治疗。

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