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首页> 外文期刊>World Journal of Gastroenterology >Oddi sphincter function after canine auto-pancreas transplantation with bladder drainage
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Oddi sphincter function after canine auto-pancreas transplantation with bladder drainage

机译：犬自体胰腺移植并膀胱引流后的Oddi括约肌功能

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AIM: Several neural and hormonal factors are known to affect motility of sphincter of Oddi (SO). The major roles of SO are to regulate the flow of bile and pancreatic juice into the duodenum and to prevent the reflux of duodenal contents into the biliary and pancreatic duct. After pancreas transplantation, graft SO was denervated and graft pancreatitis might have relations to SO motility. The motility of SO after canine pancreas transplantation with bladder drainage was investigated. METHODS: Normal canine SO manometry and pancreas graft SO manometry after pancreas transplantation with bladder drainage were performed in seven dogs respectively before and after cholecystokinin (CCK) administration. Data of SO basal pressure, contraction frequency, amplitude and motility index after transplantation and CCK administration were compared with that in controls and before CCK administration. RESULTS: SO showed regular contractions with a certain basal pressure in control dogs. After transplantation, the graft SO basal pressure and contraction frequency were higher than that in controls, but the amplitude decreased (P<0.01). There was no great difference in SO motility index. CCK administration could relax normal SO but stimulate graft SO after pancreas transplantation with bladder drainage. After CCK administration, SO basal pressure, frequency and motility index were increased significantly (P<0.05), in comparison with that before administration. The amplitude remained unchanged (P>0.05), in comparison with that before CCK administration. CONCLUSION: After auto-pancreas transplantation with bladder drainage, canine SO motility was inhibited. Basal pressure and frequency increased but amplitude decreased. CCK administration after transplantation had an inhibitory effect on canine SO instead of a relaxation effect observed in normal canine SO. This will increase the resistance of SO to the pancreatic juice flow and induce pancreatic juice stagnation and can not prevent reflux of urine and duodenal contents when the bladder pressure is increased to a certain extent, which may cause graft pancreatitis.
机译：目的：已知几种神经和激素因素会影响Oddi（SO）括约肌的运动。 SO的主要作用是调节胆汁和胰液流入十二指肠，并防止十二指肠内容物回流到胆管和胰管。胰腺移植后，移植物SO失神经，移植物胰腺炎可能与SO运动有关。研究了犬胰脏移植并膀胱引流后SO的运动能力。方法：对7只犬，在给予胆囊收缩素（CCK）前后，分别进行了正常犬SO测压和胰脏移植SO测压。比较移植和CCK给药后与对照组和CCK给药前的SO基础压，收缩频率，幅度和运动指数的数据。结果：SO在对照犬中显示出规律的收缩，并具有一定的基础压力。移植后，移植物SO的基础压力和收缩频率均高于对照组，但幅度下降（P <0.01）。 SO活力指数差异不大。 CCK给药可以使正常的SO放松，但在胰腺移植和膀胱引流后刺激移植SO。与给药前相比，CCK给药后，SO的基础压力，频率和运动指数显着增加（P <0.05）。与CCK给药前相比，振幅保持不变（P＞ 0.05）。结论：自体胰腺移植并膀胱引流后，犬SO运动被抑制。基础压力和频率增加，但幅度降低。移植后CCK的施用对犬SO具有抑制作用，而不是在正常犬SO中观察到的松弛作用。当膀胱压力在一定程度上升高时，这将增加SO对胰液流动的抵抗力并引起胰液停滞，并且不能防止尿液和十二指肠内容物的回流，这可能会导致移植胰腺炎。

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