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首页> 外文期刊>Cell Research >Redox regulation of mast cell histamine release in thioredoxin-1 (TRX) transgenic mice
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Redox regulation of mast cell histamine release in thioredoxin-1 (TRX) transgenic mice

机译：氧化还原调节硫氧还蛋白-1（TRX）转基因小鼠肥大细胞组胺的释放

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摘要

Thioredoxin-1 (TRX) is a stress-inducible redox-regulatory protein with antioxidative and anti-inflammatory effects. Here we show that the release of histamine from mast cells elicited by cross-linking of high-affinity receptor for IgE (FcεRI) was significantly suppressed in TRX transgenic (TRX-tg) mice compared to wild type (WT) mice. Intracellular reactive oxygen species (ROS) of mast cells stimulated by IgE and antigen was also reduced in TRX-tg mice compared to WT mice. Whereas there was no difference in the production of cytokines (IL-6 and TNF-α) from mast cells in response to 2,4-dinitrophenylated bovine serum albumin (DNP-BSA) stimulation in TRX-tg and WT mice. Immunological status of TRX-tg mice inclined to T helper (Th) 2 dominant in primary immune response, although there was no difference in the population of dendritic cells (DCs) and regulatory T cells. We conclude that the histamine release from mast cells in TRX-tg mice is suppressed by inhibition of ROS generation. As ROS are involved in mast cell activation and facilitate mediator release, TRX may be a key signaling molecule regulating the early events in the IgE signaling in mast cells and the allergic inflammation.
机译：硫氧还蛋白-1（TRX）是一种压力诱导型氧化还原调节蛋白，具有抗氧化和抗炎作用。在这里，我们显示与野生型（WT）小鼠相比，TRX转基因（TRX-tg）小鼠显着抑制了IgE（FcεRI）高亲和力受体交联引起的肥大细胞中组胺的释放。与WT小鼠相比，TRX-tg小鼠的IgE和抗原刺激的肥大细胞的细胞内活性氧（ROS）也降低了。而在TRX-tg和WT小鼠中，响应2，4-二硝基苯基化牛血清白蛋白（DNP-BSA）刺激，肥大细胞产生的细胞因子（IL-6和TNF-α）没有差异。 TRX-tg小鼠的免疫状态倾向于在初级免疫应答中占主导的T辅助（Th）2，尽管在树突状细胞（DCs）和调节性T细胞的种群上没有差异。我们得出结论，TRX-tg小鼠肥大细胞中的组胺释放受到ROS生成的抑制。由于ROS参与肥大细胞活化并促进介体释放，因此TRX可能是调节肥大细胞IgE信号传导的早期事件和过敏性炎症的关键信号分子。

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