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首页> 外文期刊>Chemosphere >Proteomic profile and toxicity pathway analysis in zebrafish embryos exposed to bisphenol A and di-n-butyl phthalate at environmentally relevant levels
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Proteomic profile and toxicity pathway analysis in zebrafish embryos exposed to bisphenol A and di-n-butyl phthalate at environmentally relevant levels

机译：在环境相关水平下暴露于双酚A和邻苯二甲酸二正丁酯的斑马鱼胚胎中的蛋白质组学概况和毒性途径分析

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摘要

Bisphenol A (BPA) and di-n-butyl phthalate (DBP) are well-known endocrine-disrupting chemicals (EDCs) that have human health risks. Chronic exposure to BPA and DBP increases the occurrence of human disease. Despite the potential for exposure in embryonic development, the mechanism of action of BPA and DBP on vertebrate development and disease still remains unclear. In the present study, we identified proteins and protein networks that are perturbed by BPA and DBP during zebrafish (Danio rerio) development. Zebrafish embryos were exposed to environmentally relevant levels of BPA (10 mu g/L) and DBP (50 mu g/L) for 96 h. By iTRAQ labeling quantitative proteomics, a set of 26 and 41 differentially expressed proteins were identified in BPA- and DBP-treated zebrafish embryos, respectively. Integrated toxicity analysis predicted that these proteins function in common regulatory networks that are significantly associated with developmental and metabolic disorders. Exposure to low concentrations of BPA and DBP has potential health risks in zebrafish embryos. Our results also show that BPA and DBP significantly up-regulate the expression levels of multiple network proteins, providing valuable information about the molecular actions of BPA and DBP on the developmental systems. (C) 2017 Elsevier Ltd. All rights reserved.
机译：双酚A（BPA）和邻苯二甲酸二正丁酯（DBP）是众所周知的具有破坏人体健康风险的内分泌干扰化学物质（EDC）。长期接触BPA和DBP会增加人类疾病的发生。尽管有可能在胚胎发育中暴露，但是BPA和DBP对脊椎动物发育和疾病的作用机理仍然不清楚。在本研究中，我们确定了斑马鱼（斑马鱼）发育过程中BPA和DBP干扰的蛋白质和蛋白质网络。将斑马鱼胚胎暴露于与环境相关的BPA（10μg / L）和DBP（50μg / L）浓度下96小时。通过iTRAQ标记定量蛋白质组学，分别在BPA和DBP处理的斑马鱼胚胎中鉴定出26种和41种差异表达的蛋白质。综合毒性分析预测，这些蛋白质在与发育和代谢异常显着相关的常见调节网络中起作用。暴露于低浓度的BPA和DBP对斑马鱼胚胎具有潜在的健康风险。我们的结果还表明，BPA和DBP显着上调了多种网络蛋白的表达水平，提供了有关BPA和DBP在发育系统上的分子作用的有价值的信息。 （C）2017 Elsevier Ltd.保留所有权利。

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  • 来源
    《Chemosphere》 |2018年第2期|313-320|共8页
  • 作者

    Dong Xing; Qiu Xuchun; Meng Shunlong; Xu Hai; Wu Xiangyang; Yang Ming;

  • 作者单位

    Jiangsu Univ, Inst Environm Hlth & Ecol Secur, Sch Environm & Safety Engn, Zhenjiang 212013, Jiangsu, Peoples R China;

    Jiangsu Univ, Inst Environm Hlth & Ecol Secur, Sch Environm & Safety Engn, Zhenjiang 212013, Jiangsu, Peoples R China|Kyushu Univ, Lab Marine Environm Sci, Fac Agr, Fukuoka 8128581, Japan;

    Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Key Lab Fishery Ecoenvironm Assessment & Resource, Wuxi 214081, Peoples R China;

    Jiangsu Univ, Inst Environm Hlth & Ecol Secur, Sch Environm & Safety Engn, Zhenjiang 212013, Jiangsu, Peoples R China;

    Jiangsu Univ, Inst Environm Hlth & Ecol Secur, Sch Environm & Safety Engn, Zhenjiang 212013, Jiangsu, Peoples R China;

    Shanghai Univ, Sch Environm & Chem Engn, Shanghai 200444, Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Proteomics; Toxicity pathway; Endocrine-disrupting chemicals; Bisphenol A; Di-n-butyl phthalate; Zebrafish;

    机译：蛋白质组学;毒性途径;破坏内分泌的化学物质;双酚A;邻苯二甲酸二正丁酯;斑马鱼;

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