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Cross Currents in Protein Misfolding Disorders: Interactions and Therapy

机译：蛋白质错折叠紊乱中的交叉电流：相互作用和治疗

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摘要

Protein Misfolding Disorders (PMDs) are a group of diseases characterized by the accumulation of abnormally folded proteins. Despite the wide range of proteins and tissues involved, PMDs share similar molecular and pathogenic mechanisms. Several epidemiological, clinical and experimental reports have described the co-existence of PMDs, suggesting a possible cross-talk between them. A better knowledge of the molecular basis of PMDs could have important implications for understanding the mechanisms by which these diseases appear and progress and ultimately to develop novel strategies for treatment. Due to their similar molecular mechanisms, common therapeutic strategies could be applied for the diseases in this group.
机译：蛋白质折叠错误（PMD）是一组以异常折叠的蛋白质堆积为特征的疾病。尽管涉及的蛋白质和组织范围很广，但PMD具有相似的分子和致病机理。几项流行病学，临床和实验报告已经描述了PMD的共存，表明它们之间可能存在串扰。更好地了解PMD的分子基础可能对理解这些疾病的发生和发展机理以及最终制定新的治疗策略具有重要意义。由于它们相似的分子机制，因此常见的治疗策略可用于该组疾病。

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