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Metal complex strategies for photo-uncaging the small molecule bioregulators nitric oxide and carbon monoxide

机译:光解小分子生物调节剂一氧化氮和一氧化碳的金属配合物策略

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摘要

Photochemical release (uncaging) of small molecule bioregulators (SMBs) such as nitric oxide (NO) or carbon monoxide (CO) at physiological sites offers exquisite control of timing, location and dosage. However, photo-uncaging faces two major problems that challenge its therapeutic applications: the relatively poor transmision of visible light through tissue and the need to deliver the appropriate precursors to the desired targets. In this brief review are discussed research activities that address these issues of spatial-temporal control. (C) 2018 Elsevier B.V. All rights reserved.
机译:小分子生物调节剂(SMB)(例如一氧化氮(NO)或一氧化碳(CO))在生理部位的光化学释放(开漏)可精确控制时间,位置和剂量。然而,光解开孔面临两个主要问题,这些问题挑战了其治疗应用:可见光透过组织的透射率相对较差,以及需要将适当的前体递送至所需靶标的需求。在这篇简短的综述中,讨论了解决这些时空控制问题的研究活动。 (C)2018 Elsevier B.V.保留所有权利。

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