Immunoglobulin Free Light Chains in Immune Responses

Joris van der Veeken Frank A. Redegeld

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Immunoglobulin Free Light Chains in Immune Responses

机译：免疫反应中的免疫球蛋白游离轻链

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The functional activity of immunoglobulin free light chains in mast cell-dependent hypersensitivity-like responsesnimplicates a potential role for these molecules in other immune disorders. Mast cell-bound immunoglobulin freenlight chains recognize antigen and induce mast cell activation and mediator release. Through this mechanism, immunoglobulinnfree light chains can contribute to the pathogenesis of e.g. contact hypersensitivity and non-atopic asthma. Thesenfindings shed new light on the potential role of immunoglobulin free light chains in autoimmune disorders, such as multiplensclerosis and rheumatoid arthritis. Immunoglobulin free light chain levels are increased in these disorders and correlatenwith disease activity. Further establishing the contribution of immunoglobulin free light chain-mediated mast cell activationnto the pathogenesis of chronic inflammatory diseases may lead to novel therapeutic strategies in their treatment

机译：免疫球蛋白游离轻链在肥大细胞依赖性超敏反应样反应中的功能活性暗示了这些分子在其他免疫疾病中的潜在作用。肥大细胞结合的免疫球蛋白游离链识别抗原并诱导肥大细胞活化和介质释放。通过这种机制，无免疫球蛋白的轻链可以促进例如丙型肝炎的发病。接触性超敏反应和非特应性哮喘。这些发现为免疫球蛋白游离轻链在自身免疫性疾病（如多发性硬化症和类风湿性关节炎）中的潜在作用提供了新的启示。这些疾病中免疫球蛋白的游离轻链水平增加，并与疾病活动相关。进一步确定免疫球蛋白游离轻链介导的肥大细胞活化对慢性炎性疾病发病机制的贡献可能会导致新的治疗策略

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来源
《Current Immunology Reviews》 |2008年第2期|p.88-100|共13页
作者
Joris van der Veeken Frank A. Redegeld;
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作者单位

Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science,Utrecht University, The Netherlands;

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正文语种 eng
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关键词
Immunoglobulin free light chain, mast cell, hypersensitivity, allergy, asthma, multiple sclerosis, rheumatoid arthritis; inflammatory bowel disease.;

机译：免疫球蛋白游离轻链;肥大细胞;超敏反应;过敏;哮喘;多发性硬化症;类风湿关节炎;炎症性肠病。;

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专利

1. Discordance between serum cardiac biomarker and immunoglobulin-free light-chain response in patients with immunoglobulin light-chain amyloidosis treated with immune modulatory drugs. [J] . Dispenzieri A, Dingli D, Kumar SK, American Journal of Hematology . 2010,第10期

机译：免疫调节药物治疗的免疫球蛋白轻链淀粉样变性患者的血清心脏生物标志物与无免疫球蛋白轻链反应之间的不一致。
2. Discordance between serum cardiac biomarker and immunoglobulin-free light-chain response in patients with immunoglobulin light-chain amyloidosis treated with immune modulatory drugs† [J] . Angela Dispenzieri, David Dingli, Shaji K. Kumar, AMERICAN JOURNAL OF HEMATOLOGY . 2010,第10期

机译：免疫调节药物治疗的免疫球蛋白轻链淀粉样变性患者血清心脏生物标志物与无免疫球蛋白轻链反应之间的差异†
3. Within-subject biological variation of pairs of heavy/light immunoglobulin IgM chains (HLC IgM κ and λ) is low and requires monitoring: A comparison with HLC IgA, HLC IgG, and free light immunoglobulin chains (FLC) in healthy subjects [J] . Antonín Jabor, Zdenek Kubí?ek, Jitka Komrsková, Clinica chimica acta: International journal of clinical chemistry and applied molecular biology . 2018,第期

机译：在对沉重/光免疫球蛋白IGM链（HLCIgMκ和λ）的对的主题生物学变化较低，需要监测：与HLC IgA，HLC IgG和自由轻的免疫球蛋白链（FLC）在健康受试者中进行比较
4. Immunoglobulin Free Light Chains in Hypersensitivity Reactions: Need for Crosslinking by Antigens [C] . F.A. Redegeld, S.C. Berndsen, B. Blokhuis, Collegium Internationale Allergologicum . 2007

机译：超敏反应中的免疫球蛋白免轻链：需要通过抗原交联
5. Cellular internalization and response to amyloidogenic immunoglobulin light chain. [D] . Monis, Divina Grace Fortes. 2007

机译：细胞内在化和对淀粉样蛋白生成的免疫球蛋白轻链的反应。
6. Discordance between serum cardiac biomarker and immunoglobulin-free light-chain response in patients with immunoglobulin light-chain amyloidosis treated with immune modulatory drugs [O] . Angela Dispenzieri, David Dingli, Shaji K. Kumar, -1

机译：患者血清心脏生物标志物之间的不一致免疫球蛋白游离轻链响应于与免疫球蛋白轻链淀粉样变性病与免疫调节药物治疗
7. Serum Reference Intervals and Diagnostic Ranges for Free κ and Free λ Immunoglobulin Light Chains: Relative Sensitivity for Detection of Monoclonal Light Chains [O] . Jerry A Katzmann, Raynell J Clark, Roshini S Abraham, 2002

机译：游离κ和自由λ免疫球蛋白轻链的血清参考间隔和诊断范围：检测单克隆光链的相对灵敏度
8. Classifying Noisy Protein Sequence Data: A Case Study of Immunoglobulin Light Chains; Journal article [R] . Yu, C., Zavaljevski, N., Stevens, F. J., 2005

机译：噪声蛋白质序列数据分类：免疫球蛋白光链的案例研究;杂志文章

Immunoglobulin Free Light Chains in Immune Responses

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