• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current Immunology Reviews >Sjogren's Syndrome and Lymphoma Development
【24h】

Sjogren's Syndrome and Lymphoma Development

机译：干燥综合征和淋巴瘤的发展

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Primary Sjogren's syndrome (pSS) is a systemic as well as an organ-specific autoimmune disease characterized by lymphocytic infiltration of the glandular epithelial tissue. It has been reported that pSS patients have a relatively increased risk for the development of lymphoma and various factors such as cytokine stimulation, environmental exposures and viral infections as well as genetic events may contribute to the development of lymphoma in pSS patients. Over the past few decades, numerous efforts have been undertaken to search for the relationship between lymphoma and pSS, for example advances in molecular biology for clonality analysis and well-linked register cohort studies for the predictive value of clinical, laboratory and histological findings. Despite this, mechanisms and prediction of lymphoma development in pSS patients still remain to be defined. In this review we have summarized the current knowledge concerning incidence and risk factors of lymphoma development in pSS patients. In addition, the most recent discoveries in the emergence and treatment of lymphoma in pSS patients and the possible mechanism of lymphoma development are also discussed.
机译：原发性干燥综合征（pSS）是一种全身性以及器官特异性自身免疫性疾病，其特征是腺上皮组织发生淋巴细胞浸润。据报道，pSS患者患淋巴瘤的风险相对增加，并且诸如细胞因子刺激，环境暴露和病毒感染以及遗传事件的多种因素可能导致pSS患者淋巴瘤的发展。在过去的几十年中，人们为寻找淋巴瘤与pSS之间的关系进行了许多努力，例如分子生物学在克隆性分析方面的进展以及在临床，实验室和组织学发现方面具有预测价值的关联性良好的队列研究。尽管如此，pSS患者淋巴瘤发展的机制和预测仍待确定。在这篇综述中，我们总结了有关pSS患者淋巴瘤发展的发生率和危险因素的最新知识。此外，还讨论了pSS患者淋巴瘤的出现和治疗中的最新发现以及淋巴瘤发展的可能机制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号