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首页> 外文期刊>Cytology and genetics >A Mutagenicity and Cytotoxicity Study on Limonium effusum Aqueous Extracts by Allium, Ames and MTT Tests
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A Mutagenicity and Cytotoxicity Study on Limonium effusum Aqueous Extracts by Allium, Ames and MTT Tests

机译：葱属，阿姆斯氏和MTT试验研究莲提取物的致突变性和细胞毒性

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摘要

Nowadays plants or plant extracts have become very important for alternative medicine. Plants and their extracts have many therapeutical advantages but some of them are potentially toxic, mutagenic, carcinogenic and teratogenic. Root, stem and leaf parts of Limonium effusum were used in this study and this species is an endemic species for Turkey. Mutagenic and cytotoxic effects of root, stem and leaf aqueous extracts were observed with Allium, Ames and MTT tests. Allium root growth inhibition test and mitotic index studies showed that aqueous extracts have dose-dependent toxic effects. Chromosome aberration studies indicated that especially sticky chromosome, anaphase-telophase disorder and laggard chromosome anomalies were highly observed. Ames test performed with Limonium effusum root aqueous extracts, showed weak mutagenic effects in Salmonella typhimurium TA98 strain with S9. MTT test based on mitochondrial activity indicated that most of the aqueous extracts have cytotoxic effects. This study aimed to determine the possible mutagenic and cytotoxic effects of L. effusum aqueous extracts by using bacterial, plant and mammalian cells. This research showed that some low concentrations of the L. effusum extracts have inhibited cytotoxic effects but high concentrations have induced cytotoxicity. On the other hand only a weak mutagenic activity was identified by Ames test with TA98 S9(+).
机译：如今，植物或植物提取物对于替代医学已经变得非常重要。植物及其提取物具有许多治疗优势，但其中一些具有潜在的毒性，致突变性，致癌性和致畸性。这项研究使用了茅草属植物的根，茎和叶部分，该种是土耳其的特有种。根，茎和叶水提物的诱变和细胞毒性作用通过葱属，Ames和MTT试验观察到。葱根生长抑制试验和有丝分裂指数研究表明，水提物具有剂量依赖性的毒性作用。染色体畸变研究表明，尤其是粘性染色体，后期-末期疾病和落后染色体异常。用柠檬茅根根水提取物进行的Ames试验显示，鼠伤寒沙门氏菌TA98菌株中带有S9的诱变作用较弱。基于线粒体活性的MTT测试表明，大多数水提物具有细胞毒性作用。这项研究的目的是通过使用细菌，植物和哺乳动物细胞来确定出汗乳杆菌水提取物的可能的诱变和细胞毒性作用。这项研究表明，一些低浓度的紫草提取物抑制了细胞毒性作用，但高浓度诱导了细胞毒性。另一方面，通过TA98 S9（+）的Ames测试只能鉴定出弱的诱变活性。

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  • 来源
    《Cytology and genetics》 |2015年第2期|125-133|共9页
  • 作者

    Eren Y.; Ozata A.; Konuk M.; Akyil D.; Liman R.;

  • 作者单位

    Suleyman Demirel Univ, Fac Educ, Dept Sci Educ, TR-32260 Isparta, Turkey;

    Anadolu Univ, Fac Sci, Dept Biol, TR-26470 Eskisehir, Turkey;

    Uskudar Univ, Fac Engn & Nat Sci, Dept Mol Biol & Genet, TR-34662 Istanbul, Turkey;

    Afyon Kocatepe Univ, Fac Sci & Arts, Dept Biol, TR-03200 Afyon, Turkey;

    Usak Univ, Fac Sci & Arts, Dept Mol Biol & Genet, TR-64200 Usak, Turkey;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Limonium effusum; Allium test; Ames test; MTT test;

    机译：可用的Limonium倒出;Allium测试;Ames测试;MTT测试;

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