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Analysis of CTLA4 Gene 49A/G Polymorphism Association with Development of Allergic Rhinitis

机译：CTLA4基因49A / G多态性与变应性鼻炎发生关系的分析

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摘要

CTLA4 gene 49A/G polymorphism was analyzed in 44 patients with allergic rhinitis and 70 nominally healthy donors of the Uzbek population. The unfavorable allele rate of this polymorphism in general studied groups and control groups did not differ significantly; it was 73.3 and 72.9% respectively. A comparative analysis of the distribution of CTLA4 gene 49A/G polymorphism in groups of patients with allergic rhinitis, depending on the clinical course and patient's gender, with the control groups did not reveal statistically significant differences. However, in patients with year-round forms of allergic rhinitis, the rate of the functionally unfavorable allele 49A/G of CTLA4 gene was almost 1.29 times higher than the same rate in the group with the seasonal form and the slightly higher than the rate in the control group.
机译：在44名过敏性鼻炎患者和70名名义上健康的乌兹别克人供体中分析了CTLA4基因49A / G多态性。在一般研究组和对照组中，这种多态性的不利等位基因率没有显着差异。分别是73.3％和72.9％。根据临床病程和性别，对过敏性鼻炎患者组中CTLA4基因49A / G多态性分布的比较分析与对照组之间无统计学差异。然而，在患有全年变应性鼻炎的患者中，CTLA4基因在功能上不利的等位基因49A / G的发生率比季节性形式的组高约1.29倍，略高于季节性变应性鼻炎。对照组。

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  • 来源
    《Cytology and genetics》 |2010年第3期|P.140-143|共4页
  • 作者

    V. Sh. Alieva; Kh. Ya. Karimov; A. A. Nazarov; S. S. Arifov; K. T. Boboev;

  • 作者单位

    Republican Scientific Specialized Centre of Allergology, MZ Republic of Uzbekistan, Tashkent;

    Scientific Research Institute of Hematology and Blood Transfusion, MZ Republic of Uzbekistan, Tashkent;

    rnRepublican Scientific Specialized Centre of Allergology, MZ Republic of Uzbekistan, Tashkent;

    Scientific Research Institute of Hematology and Blood Transfusion, MZ Republic of Uzbekistan, Tashkent;

    rnScientific Research Institute of Hematology and Blood Transfusion, MZ Republic of Uzbekistan, Tashkent;

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