Role Of Sirnas And Mirnas In The Processes Of Rna-mediated Gene Silencing During Viral Infections

I. Krulko; D. Ustyanenko; V. Polischuk

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Role Of Sirnas And Mirnas In The Processes Of Rna-mediated Gene Silencing During Viral Infections

机译：Sirnas和Mirnas在病毒感染过程中Rna介导的基因沉默过程中的作用。

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Phenomenon of RNA-induced gene silencing is a highly conservative mechanism amongrneukary-otic organisms. Several classes of small RNAs (siRNAs and miRNAs) 21-25 nt in length, which play a significant role in the processes of development of an organism, occurred important components of antiviral defence in animals and plants. This review shortly descrihes the main stages of gene silencing mechanism, features of antiviral RNA silencing in plants, invertebrates, mammals, ways of suppression of RNA-interference by viruses, as well as possible approaches of utilization of abovementioned phenomenon for struggling against viral infections.

机译：RNA诱导的基因沉默现象是神经核生物中高度保守的机制。长度在21-25 nt的几类小RNA（siRNA和miRNA）在生物体的发育过程中起着重要作用，是动植物抗病毒防御的重要组成部分。本文简要介绍了基因沉默机制的主要阶段，植物，无脊椎动物，哺乳动物中抗病毒RNA沉默的特征，病毒抑制RNA干扰的方式以及利用上述现象抗击病毒感染的可能方法。

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《Cytology and genetics》 |2009年第1期|63-72|共10页
作者
I. Krulko; D. Ustyanenko; V. Polischuk;
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正文语种 eng
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关键词
gene silencing; interference; transformation; antiviral; sirnas; mirnas;

机译：基因沉默;干扰;转化;抗病毒;西拉纳斯;mirnas;

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1. Post-transcriptional gene silencing by siRNAs and miRNAs [J] . Filipowicz W, Jaskiewicz L, Kolb FA, Current Opinion in Structural Biology . 2005,第3期

机译：siRNA和miRNA转录后基因沉默
2. Integration of miRNA and gene expression profiles suggest a role for miRNAs in the pathobiological processes of acute Trypanosoma cruzi infection [J] . Ludmila Rodrigues Pinto Ferreira, Frederico Moraes Ferreira, Laurie Laugier, Scientific reports. . 2017,第1期

机译：miRNA和基因表达谱的整合表明MiRNA在急性脑瘤Cruzi感染的病理学过程中的作用
3. RNA-mediated epigenetic modifications of an endogenous gene targeted by a viral vector: a potent gene silencing system to produce a plant that does not carry a transgene but has altered traits. [J] . Kanazawa A., Inaba J., Kasai M., Plant signaling & behavior . 2011,第8期

机译：RNA介导的病毒载体靶向的内源基因的表观遗传修饰：一种有效的基因沉默系统，可产生不携带转基因但已改变性状的植物。
4. Genetics in viral hepatitis: role of HLA class I and II alleles in hepatitis C virus infection [C] . R.THIMME, C. NEUMANN-HAEFELI Falk Symposium . 2007

机译：病毒性肝炎的遗传学：HLA I类和II等位基因在丙型肝炎病毒感染中的作用
5. Novel roles of the conserved Argonaute proteins during mammalian development: From miRNA biogenesis to gene silencing. [D] . Cheloufi, Sihem. 2010

机译：保守的Argonaute蛋白在哺乳动物发育过程中的新作用：从miRNA生物发生到基因沉默。
6. Role of siRNAs and miRNAs in the processes of RNA-mediated gene silencing during viral infections [O] . I. Krulko, D. Ustyanenko, V. Polischuk -1

机译：siRNA和miRNA在病毒感染期间RNA介导的基因沉默过程中的作用
7. Roles of siRNAs and miRNAs in host responses to virus infection: Identification and characterization of a novel viral suppressor of RNA silencing [O] . CHEN JUN 2004

机译：siRNA和miRNA在宿主对病毒感染的应答中的作用：RNA沉默的新型病毒抑制剂的鉴定和表征

Role Of Sirnas And Mirnas In The Processes Of Rna-mediated Gene Silencing During Viral Infections

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