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首页> 外文期刊>Biomedical Optics Express >Motion-compensated hand-held common-path Fourier-domain optical coherence tomography probe for image-guided intervention
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Motion-compensated hand-held common-path Fourier-domain optical coherence tomography probe for image-guided intervention

机译：运动补偿手持式共路径傅里叶域光学相干断层扫描探头，用于图像引导干预

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A motion-compensated, hand-held, common-path, Fourier-domain optical coherence tomography imaging probe has been developed for image-guided intervention during microsurgery. A hand-held prototype instrument was achieved by integrating an imaging fiber probe inside a stainless steel needle and attached to the ceramic shaft of a piezoelectric motor housed in an aluminum handle. The fiber probe obtains A-scan images. The distance information was extracted from the A-scans to track the sample surface distance and a fixed distance was maintained by a feedback motor control which effectively compensated hand tremor and target movements in the axial direction. Real-time data acquisition, processing, motion compensation, and image visualization and saving were implemented on a custom CPU-GPU hybrid architecture. We performed 10× zero padding to the raw spectrum to obtain 0.16 µm position accuracy with a compensation rate of 460 Hz. The root-mean-square error of hand-held distance variation from target position was measured to be 2.93 µm. We used a cross-correlation maximization-based shift correction algorithm for topology correction. To validate the system, we performed free-hand OCT M-scan imaging using various samples.
机译：已经开发了一种运动补偿，手持式，公共路径，傅里叶域光学相干断层扫描成像探头，用于显微外科手术中的图像引导干预。手持式原型仪器是通过将成像光纤探针集成在不锈钢针内并连接到铝柄中的压电马达的陶瓷轴而制成的。光纤探头获取A扫描图像。从A扫描中提取距离信息以跟踪样品表面距离，并通过反馈电动机控制来保持固定距离，该反馈电动机控制可有效补偿手部震颤和目标在轴向的运动。实时数据采集，处理，运动补偿以及图像可视化和保存是在自定义CPU-GPU混合体系结构上实现的。我们对原始频谱进行了10倍零填充，以460 Hz的补偿率获得了0.16 µm的位置精度。手持距离目标位置变化的均方根误差经测量为2.93 µm。我们使用基于互相关最大化的移位校正算法进行拓扑校正。为了验证系统，我们使用各种样品进行了免费的OCT M扫描成像。

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