A thermostable archaeal S-adenosylmethionine synthetase: a promising tool to improve the synthesis of adenosylmethionine analogs of biotechnological interest

Marina Porcelli; Concetta Paola Ilisso; Laura Mosca; Giovanna Cacciapuoti

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A thermostable archaeal S-adenosylmethionine synthetase: a promising tool to improve the synthesis of adenosylmethionine analogs of biotechnological interest

机译：热稳定的古细菌S-腺苷甲硫氨酸合成酶：改善生物技术兴趣的腺苷甲硫氨酸类似物合成的有前途的工具

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The naturally and widely occurring sulfonium compound, S-adenosylmethionine (AdoMet), one of nature's most versatile molecules, is biosynthesized from methionine and ATP by AdoMet synthetase or methionine adenosyltransferase (MAT) in a 2-step reaction in which the energy-rich sulfonium compound is formed by dephosphorylation of ATP. All living cells, with the only exception of some parasites and infectious agents, express MAT.

机译：天然和广泛存在的sulf化合物S-腺苷甲硫氨酸（AdoMet）是自然界中用途最广泛的分子之一，是通过AdoMet合成酶或蛋氨酸腺苷转移酶（MAT）在2步反应中由甲硫氨酸和ATP生物合成的，其中富含能量的2-通过ATP的去磷酸化形成化合物。除某些寄生虫和传染原外，所有活细胞均表达MAT。

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《Bioengineered》 |2015年第3期|共3页
作者
Marina Porcelli; Concetta Paola Ilisso; Laura Mosca; Giovanna Cacciapuoti;
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1. A thermostable archaeal S-adenosylmethionine synthetase:a promising tool to improve the synthesis of adenosylmethionineanalogs of biotechnological interest [J] . Marina Porcelli, Concetta Paola Ilisso, Laura Mosca, Bioengineered . 2015,第3期

机译：热稳定的古细菌S-腺苷甲硫氨酸合成酶：一种有希望的工具，以提高生物技术兴趣的腺苷甲硫氨酸类似物的合成
2. FERONIA receptor kinase interacts with S-adenosylmethionine synthetase and suppresses S-adenosylmethionine production and ethylene biosynthesis in Arabidopsis [J] . Mao Dandan, Yu Feng, Li Jian, Plant, Cell & Environment . 2015,第12期

机译：FERONIA受体激酶与S-腺苷甲硫氨酸合成酶相互作用并抑制拟南芥中S-腺苷甲硫氨酸的产生和乙烯的生物合成
3. Crystal structure of the s-adenosylmethionine synthetase ternary complex: a novel catalytic mechanism of s-adenosylmethionine synthesis from ATP and met(,). [J] . Komoto J, Yamada T, Takata Y, Biochemistry . 2004,第7期

机译：s-腺苷甲硫氨酸合成酶三元复合物的晶体结构：由ATP和met（，）合成s-腺苷甲硫氨酸的新型催化机制。
4. ENHANCING PHOTOSYNTHESIS BY IMPROVING RUBISCO CARBOXYLASE ACTIVITY AND SPECIFICITY, AND RUBISCO ACTIVASE THERMOSTABILITY THROUGH DNA SHUFFLING [C] . Genial Zhu, Itzhak Kurek, Thorn Trae, International Congress of Photosynthesis . 2005

机译：通过改善Rubisco羧化酶活性和特异性，通过DNA洗片来增强光合作用和Rubisco Activease热稳定性
5. Mechanistic studies on the radical S-adenosylmethionine enzymes involved in molybdopterin, thiamin and vitamin B12 biosynthesis. [D] . Mehta, Angad Pankaj. 2015

机译：涉及钼蝶呤，硫胺素和维生素B12生物合成的自由基S-腺苷甲硫氨酸酶的机理研究。
6. A thermostable archaeal S-adenosylmethionine synthetase: a promising tool to improve the synthesis of adenosylmethionine analogs of biotechnological interest [O] . Marina Porcelli, Concetta Paola Ilisso, Laura Mosca, 2015

机译：热稳定的古细菌S-腺苷甲硫氨酸合成酶：改善生物技术兴趣的腺苷甲硫氨酸类似物合成的有前途的工具
7. Phytohormonal regulation of S-adenosylmethionine synthetase and S-adenosylmethionine levels in dwarf pea epicotyls [O] . Mathur Mukul, Sachar R.C. 1991

机译：矮豌豆上胚轴中S-腺苷甲硫氨酸合成酶和S-腺苷甲硫氨酸水平的植物激素调节

A thermostable archaeal S-adenosylmethionine synthetase: a promising tool to improve the synthesis of adenosylmethionine analogs of biotechnological interest

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