...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>BMC Evolutionary Biology >The genome sequence of Brucella pinnipedialis B2/94 sheds light on the evolutionary history of the genus Brucella
【24h】

The genome sequence of Brucella pinnipedialis B2/94 sheds light on the evolutionary history of the genus Brucella

机译：布鲁氏菌布鲁氏菌B2 / 94的基因组序列为布鲁氏菌属的进化史提供了启示

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Since the discovery of the Malta fever agent, Brucella melitensis, in the 19th century, six terrestrial mammal-associated Brucella species were recognized over the next century. More recently the number of novel Brucella species has increased and among them, isolation of species B. pinnipedialis and B. ceti from marine mammals raised many questions about their origin as well as on the evolutionary history of the whole genus. We report here on the first complete genome sequence of a Brucella strain isolated from marine mammals, Brucella pinnipedialis strain B2/94. A whole gene-based phylogenetic analysis shows that five main groups of host-associated Brucella species rapidly diverged from a likely free-living ancestor close to the recently isolated B. microti. However, this tree lacks the resolution required to resolve the order of divergence of those groups. Comparative analyses focusing on a) genome segments unshared between B. microti and B. pinnipedialis, b) gene deletion/fusion events and c) positions and numbers of Brucella specific IS711 elements in the available Brucella genomes provided enough information to propose a branching order for those five groups. In this study, it appears that the closest relatives of marine mammal Brucella sp. are B. ovis and Brucella sp. NVSL 07-0026 isolated from a baboon, followed by B. melitensis and B. abortus strains, and finally the group consisting of B. suis strains, including B. canis and the group consisting of the single B. neotomae species. We were not able, however, to resolve the order of divergence of the two latter groups.
机译：自19世纪发现马耳他发烧菌布鲁氏菌以来，在下个世纪就认识到6种与陆地哺乳动物有关的布鲁氏菌物种。最近，新颖的布鲁氏菌属种类增加了，其中，从海洋哺乳动物中分离出Pinnipedialis物种和B. ceti物种引起了关于其起源以及整个属的进化史的许多问题。我们在这里报告分离自海洋哺乳动物布鲁氏菌布鲁尼氏菌菌株B2 / 94布鲁氏菌菌株的第一个完整的基因组序列。整个基于基因的系统发育分析表明，与寄主相关的布鲁氏菌的五个主要类别迅速从可能的自由祖先靠近最近分离的小芽孢杆菌分离。但是，该树缺乏解决这些组的发散顺序所需的分辨率。比较分析着重于a）微小芽孢杆菌和pinnipedialis之间不共享的基因组片段，b）基因缺失/融合事件，以及c）可用布鲁氏菌基因组中布鲁氏菌特异性IS711元件的位置和数量，提供了足够的信息来提出分支顺序这五个小组。在这项研究中，似乎是海洋哺乳动物布鲁氏菌属的近亲。是B. ovis和Brucella sp.。从狒狒中分离出NVSL 07-0026，然后是B. melitensis和B.abortus菌株，最后是由B. suis菌株组成的组，包括犬B. canis和单个B. neotomae物种。但是，我们无法解决后两个群体的分歧顺序。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号