Synthesis and SAR of the antistaphylococcal natural product nematophin from Xenorhabdus nematophila

Frank Wesche; Hélène Adihou; Thomas A. Wichelhaus; Helge B. Bode

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Synthesis and SAR of the antistaphylococcal natural product nematophin from Xenorhabdus nematophila

机译：嗜油线虫（Xenorhabdus nematophila）抗葡萄球菌天然产物线虫素的合成和SAR

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The repeated and improper use of antibiotics had led to an increased number of multiresistant bacteria. Therefore, new lead structures are needed. Here, the synthesis and an expanded structure–activity relationship of the simple and antistaphylococcal amide nematophin from Xenorhabdus nematophila and synthetic derivatives are described. Moreover, the synthesis of intrinsic fluorescent derivatives, incorporating azaindole moieties was achieved for the first time.

机译：抗生素的反复和不当使用导致了多重耐药菌数量的增加。因此，需要新的引线结构。在这里，描述了来自嗜血线虫（Xenorhabdus nematophila）和合成衍生物的简单和抗葡萄球菌酰胺线虫素的合成及其扩展的构效关系。此外，首次实现了结合了氮杂吲哚部分的内在荧光衍生物的合成。

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《Beilstein journal of organic chemistry.》 |2019年第1期|共7页
作者
Frank Wesche; Hélène Adihou; Thomas A. Wichelhaus; Helge B. Bode;
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中图分类有机化学;
关键词
azaindolefluorescent dyeMRSAnematophinStaphylococcus aureus;

机译：氮杂吲哚荧光染料金黄色葡萄球菌金黄色葡萄球菌;

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机译：PhI（OAc）2在合成中的新应用：有效的抗肿瘤天然产物Psymberin / Irciniastatin A的全合成和SAR开发
2. New Applications of PhI(OAc)2 in Synthesis: Total Synthesis and SAR Development of Potent Antitumor Natural Product Psymberin/Irciniastatin A [J] . Ning Shao, Xianhai Huang, Anandan Palani, Synthesis: International Journal of Methods in Synthetic Organic Chemistry . 2009,第17期

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3. Natural Product-Based Antibiotics: Synthesis and SAR-Studies [J] . Prusov Evgeny V. Current pharmaceutical design . 2016,第12期

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4. Purification and comparison of anti-feeding proteins between extracellular and intracellular protein of Xenorhabdus nematophila var. Pekingensis [C] . X F Yang, B J Yang, H W Yang, International Plant Protection Congress . 2007

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5. A De Novo Approach Towards Glycosylation using Iterative Pd-/B-Dual Catalysis: Applications in Natural Products Synthesis, Digitoxin analogues, Oligomannose motifs and their SAR Studies. [D] . Bajaj, Sumit O. 2015

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6. Synthesis and SAR of the antistaphylococcal natural product nematophin from Xenorhabdus nematophila [O] . Frank Wesche, Hélène Adihou, Thomas A Wichelhaus, 2019

机译：嗜油线虫（Xenorhabdus nematophila）抗葡萄球菌天然产物线虫素的合成与合成孔径雷达（SAR）
7. Synthesis and SAR of the antistaphylococcal natural product nematophin from Xenorhabdus nematophila [O] . Frank Wesche, Hélène Adihou, Thomas A Wichelhaus, 2019

机译：来自Xenorhabdus nematophila的抗视性天然产物Nematophin的合成和SAR

Synthesis and SAR of the antistaphylococcal natural product nematophin from Xenorhabdus nematophila

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