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首页> 外文期刊>BMC Urology >Ureteral reconstruction using a tapered non-vascularized bladder graft: an experimental study in a canine animal model
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Ureteral reconstruction using a tapered non-vascularized bladder graft: an experimental study in a canine animal model

机译：使用锥形非血管化膀胱移植物进行输尿管重建：犬类动物模型的实验研究

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Reconstruction of ureteral defects and strictures remains problematic for urologists. We aimed to investigate the possibility of a tapered non-vascularized bladder graft as a novel substitute for ureteral reconstruction. This experimental study was conducted on nine beagles. Under general anesthesia, a full-thickness graft with 5–6?cm in length was disassociated from the anterior upper wall of the bladder, and tapered into 1/3 to 1/2 thickness, remaining the urothelial surface. After removal of 5?cm of right-sided mid-ureter, the tapered bladder graft was tubularized along the long axis and then respectively anastomosed to the upper and lower stumps of the ureter. A retrograde urography through a cystostomy was performed 8?weeks after the ureteral reconstruction. The animals were euthanized, and histopathologic examinations of the neoureters were performed. There were no severe complications during postoperative follow-up. The urography indicated patent urine excretion and no fistula or stenosis. Histopathologic examinations of the neoureters showed open lumen with urothelial lining. Nutrient vessels were observed in healthy submucosa, lamina muscularis and peripheral connective tissue. Our study implied that ureteral reconstruction by a tapered non-vascularized bladder graft was anatomically possible in our animal model. Further studies are expected to confirm long-term and functional outcomes.
机译：输尿管缺损和狭窄的重建对于泌尿科医师仍然是个问题。我们旨在研究锥形非血管化膀胱移植作为输尿管重建术的新型替代方法的可能性。这项实验研究是对九只小猎犬进行的。在全身麻醉下，将长度为5-6？cm的全厚度移植物从膀胱前上壁分离，并逐渐变细为1/3至1/2厚度，保留尿路上皮表面。切除右侧输尿管的5？cm后，将锥形膀胱移植物沿长轴管状化，然后分别与输尿管的上，下残端吻合。输尿管重建术后8周，通过膀胱造口术进行了逆行尿路造影。对动物实施安乐死，并对新输尿管进行组织病理学检查。术后随访期间无严重并发症。输尿管造影显示尿液排泄明显，无瘘管或狭窄。新生儿输尿管的组织病理学检查显示管腔开放，并有尿路上皮衬里。在健康的粘膜下层，肌层和周围结缔组织中观察到营养血管。我们的研究表明，在我们的动物模型中，通过锥形无血管化膀胱移植物进行输尿管重建是可能的。期望进一步的研究可以证实长期和功能性结果。

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