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首页> 外文期刊>BMC Neuroscience >Exercise challenge alters Default Mode Network dynamics in Gulf War Illness
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Exercise challenge alters Default Mode Network dynamics in Gulf War Illness

机译：锻炼挑战改变了海湾战争疾病中的默认模式网络动态

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Gulf War Illness (GWI) affects 30% of veterans from the 1991 Gulf War and has no known cause. Everyday symptoms include pain, fatigue, migraines, and dyscognition. A striking syndromic feature is post-exertional malaise (PEM). This is recognized as an exacerbation of everyday symptoms following a physically stressful or cognitively demanding activity. The underlying mechanism of PEM is unknown. We previously reported a novel paradigm that possibly captured evidence of PEM by utilizing fMRI scans taken before and after sub-maximal exercises. We hypothesized that A) exercise would be a sufficient physically stressful activity to induce PEM and B) Comparison of brain activity before and after exercise would provide evidence of PEM’s effect on cognition. We reported two-exercise induced GWI phenotypes with distinct changes in brain activation patterns during the completion of a 2-back working memory task (also known as two-back??zero-back). Here we report unanticipated findings from the reverse contrast (zero-back??two-back), which allowed for the identification of task-related deactivation patterns. Following exercise, patients developed a significant increase in deactivation patterns within the Default Mode Network (DMN) that was not seen in controls. The DMN is comprised of regions that are consistently down regulated during external goal-directed activities and is often altered within many neurological disease states. Exercise-induced alterations within the DMN provides novel evidence of GWI pathophysiology. More broadly, results suggest that task-related deactivation patterns may have biomarker potential in Gulf War Illness.
机译：海湾战争疾病（GWI）影响1991年海湾战争中30％的退伍军人，并且原因不明。日常症状包括疼痛，疲劳，偏头痛和听觉障碍。显着的综合症状是劳累后不适（PEM）。这被认为是在承受身体压力或认知要求的活动后加剧日常症状。 PEM的潜在机制尚不清楚。我们之前报道了一种新颖的范例，该范例可能通过利用次最大运动前后的功能磁共振成像扫描来捕获PEM的证据。我们假设A）运动是足以诱发PEM的身体压力活动，而B）运动前后大脑活动的比较将提供PEM对认知的影响的证据。我们报告了两运动诱发的GWI表型，在完成2后背工作记忆任务（也称为2后背零后背）期间，大脑激活模式发生了明显变化。在这里，我们报告了来自反向对比（零后背→双向后背）的出乎意料的发现，该发现可用于识别与任务相关的停用模式。运动后，患者在默认模式网络（DMN）内的失活模式显着增加，而对照组则没有。 DMN由在外部目标定向活动期间始终被下调的区域组成，并且经常在许多神经系统疾病状态内发生变化。 DMN内运动引起的改变为GWI病理生理提供了新的证据。更广泛地说，结果表明与任务相关的失活模式可能在海湾战争疾病中具有生物标志物的潜力。

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