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首页> 外文期刊>BMC Nephrology >Diastolic function is a strong predictor of mortality in patients with chronic kidney disease
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Diastolic function is a strong predictor of mortality in patients with chronic kidney disease

机译：舒张功能是慢性肾脏病患者死亡率的强力预测指标

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Background Cardiovascular disease is a major cause of death in patients with stage 4–5 Chronic Kidney disease (CKD, eGFR Methods We conducted a prospective observational cohort study of 153 CKD patients between 2007 and 2009. All patients underwent echocardiography at baseline and were followed for a mean of 2.6?years using regular clinic visits and review of files and hospital presentations to record the incidence of cardiovascular events and death. Results Of 153 patients enrolled, 57 (37%) were on dialysis and 45 (78%) of these patients were on haemodialysis. An enlarged LV was present in 32% of patients and in 22% the LVEF was below 55%. LV mass index was increased in 75% of patients. Some degree of diastolic dysfunction was present in 85% of patients and 35% had grade 2 or higher diastolic dysfunction. During follow up 41 patients (27%) died, 15 (39%) from cardiovascular causes. Mortality was 24.0% in the non-dialysis patients versus 31.6% in patients on dialysis (p=ns). On multivariate analysis age >75?years, previous history of MI, diastolic dysfunction and detectable serum troponin T were significant independent predictor of mortality (P Conclusion Patients with stage 4–5 CKD had a mortality rate of 27% over a mean follow up of 2.6?years. Age >75?years, history of MI, diastolic dysfunction and troponin T were independent predictors of mortality.
机译：背景技术心血管疾病是4-5期慢性肾脏病（CKD，eGFR方法）患者的主要死亡原因。我们在2007年至2009年之间对153名CKD患者进行了一项前瞻性观察性队列研究。所有患者均在基线时接受了超声心动图检查，并随访。平均2.6年，通过定期的临床就诊以及文件和医院报告的回顾来记录心血管事件和死亡的发生率，结果纳入153例患者，其中57例（37％）接受透析，其中45例（78％）接受血液透析的患者中，有32％的患者出现左心室扩大，22％的左室射血分数低于55％; 75％的患者左室重量指数增加; 85％的患者和35岁的患者存在一定程度的舒张功能障碍％患有2级或更高级别的舒张功能障碍。在随访期间，有41例患者（27％）死亡，15例（39％）由心血管原因引起;非透析患者的死亡率为24.0％，而透析患者的死亡率为31.6％（p = ns ）。在multiv上ariate分析年龄> 75岁，MI的既往史，舒张功能障碍和可检测的血清肌钙蛋白T是死亡率的重要独立预测因素（P结论CKD 4-5期患者的死亡率为27％，平均随访2.6 ？年份。年龄> 75岁，MI史，舒张功能障碍和肌钙蛋白T是死亡率的独立预测因子。

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