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首页> 外文期刊>BMC Pediatrics >Development of lung function in very low birth weight infants with or without bronchopulmonary dysplasia: Longitudinal assessment during the first 15 months of corrected age
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Development of lung function in very low birth weight infants with or without bronchopulmonary dysplasia: Longitudinal assessment during the first 15 months of corrected age

机译：具有或不具有支气管肺发育异常的极低出生体重婴儿的肺功能发展：在校正年龄的前15个月内进行纵向评估

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Background Very low birth weight (VLBW) infants ( Methods Comprehensive lung function assessment was performed at about 50, 70, and 100 weeks of postmenstrual age in 55 sedated VLBW infants (29 with former BPD [O2 supplementation was given at 36 weeks of gestational age] and 26 VLBW infants without BPD [controls]). Mean gestational age (26 vs. 29 weeks), birth weight (815 g vs. 1,125 g), and the proportion of infants requiring mechanical ventilation for ≥7 d (55% vs. 8%), differed significantly between BPD infants and controls. Results Both body weight and length, determined over time, were persistently lower in former BPD infants compared to controls, but no significant between-group differences were noted in respiratory rate, respiratory or airway resistance, functional residual capacity as determined by body plethysmography (FRCpleth), maximal expiratory flow at the FRC (V'max FRC), or blood gas (pO2, pCO2) levels. Tidal volume, minute ventilation, respiratory compliance, and FRC determined by SF6 multiple breath washout (representing the lung volume in actual communication with the airways) were significantly lower in former BPD infants compared to controls. However, these differences became non-significant after normalization to body weight. Conclusions Although somatic growth and the development of some lung functional parameters lag in former BPD infants, the lung function of such infants appears to develop in line with that of non-BPD infants when a body weight correction is applied. Longitudinal lung function testing of preterm infants after discharge from hospital may help to identify former BPD infants at risk of incomplete recovery of respiratory function; such infants are at risk of later respiratory problems.
机译：背景极低出生体重（VLBW）婴儿（方法）对55例镇静性VLBW婴儿（其中29例以前有BPD [O 2 补充”）在月经后约50、70和100周进行了全面的肺功能评估在36周胎龄和26名无BPD的VLBW婴儿中进行[对照组]），平均胎龄（26对29周），出生体重（815 g对1,125 g）和需要机械通气的婴儿比例≥7 d（55％vs. 8％），BPD婴儿与对照组之间存在显着差异。结果随着时间的推移，测定的前BPD婴儿的体重和身长均持续低于对照组，但组间无显着差异在呼吸频率，呼吸或呼吸道阻力，身体体积描记法（FRC pleth ）确定的功能残余容量，FRC处的最大呼气流量（V'max FRC ）或血气（pO 2 ，pCO 2 ）水平。潮气量，与对照组相比，前BPD婴儿的分钟通气量，呼吸顺应性和由SF6多次呼吸冲刷确定的FRC（代表实际与气道连通的肺体积）显着降低。然而，这些差异在标准化为体重后变得不显着。结论尽管前BPD婴儿的体细胞生长和某些肺功能参数的发展滞后，但当进行体重校正时，此类婴儿的肺功能似乎与非BPD婴儿的肺功能一致。早产儿出院后进行纵向肺功能测试可能有助于确定前BPD婴儿处于呼吸功能不完全恢复的风险;这样的婴儿有以后发生呼吸系统疾病的风险。

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