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首页> 外文期刊>Cell discovery. >Autologous iPSC-derived dopamine neuron transplantation in a nonhuman primate Parkinson’s disease model
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Autologous iPSC-derived dopamine neuron transplantation in a nonhuman primate Parkinson’s disease model

机译：非人类灵长类帕金森病模型中的自体iPSC衍生的多巴胺神经元移植

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Autologous dopamine (DA) neurons are a new cell source for replacement therapy of Parkinson’s disease (PD). In this study, we tested the safety and efficacy of autologous induced pluripotent stem cell (iPSC)-derived DA cells for treatment of a cynomolgus monkey PD model. Monkey bone marrow mesenchymal cells were isolated and induced to iPSCs, followed by differentiation into DA cells using a method with high efficiency. Autologous DA cells were introduced into the brain of a cynomolgus monkey PD model without immunosuppression; three PD monkeys that had received no grafts served as controls. The PD monkey that had received autologous grafts experienced behavioral improvement compared with that of controls. Histological analysis revealed no overgrowth of grafts and a significant number of surviving A9 region-specific graft-derived DA neurons. The study provided a proof-of-principle to employ iPSC-derived autologous DA cells for PD treatment using a nonhuman primate PD model.
机译：自体多巴胺（DA）神经元是帕金森氏病（PD）替代疗法的新细胞来源。在这项研究中，我们测试了自体诱导多能干细胞（iPSC）衍生的DA细胞治疗食蟹猴PD模型的安全性和有效性。分离猴骨髓间充质细胞并将其诱导为iPSC，然后使用高效方法分化为DA细胞。自体DA细胞被引入到食蟹猴PD模型的大脑中而没有免疫抑制;三只没有接受移植的PD猴子作为对照。与对照组相比，接受自体移植的PD猴子的行为改善。组织学分析显示移植物没有过度生长，并且存在大量存活的A9区域特异性移植物衍生的DA神经元。该研究提供了使用非人类灵长类动物PD模型将iPSC衍生的自体DA细胞用于PD治疗的原理证明。

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