Polo-like kinase 4: the odd one out of the family

James E Sillibourne; Michel Bornens

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Polo-like kinase 4: the odd one out of the family

机译：马球样激酶4：家族中的奇数之一

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Polo-like kinase 4 (PLK4) is a unique member of the Polo-like family of kinases that shares little homology with its siblings and has an essential role in centriole duplication. The turn-over of this kinase must be strictly controlled to prevent centriole amplification. This is achieved, in part, by an autoregulatory mechanism, whereby PLK4 autophosphorylates residues in a PEST sequence located carboxy-terminal to its catalytic domain. Phosphorylated PLK4 is subsequently recognized by the SCF complex, ubiquitinylated and targeted to the proteasome for degradation. Recent data have also shown that active PLK4 is restricted to the centrosome, a mechanism that could serve to prevent aberrant centriole assembly elsewhere in the cell. While significant advances have been made in understanding how PLK4 is regulated it is certain that additional regulatory mechanisms exist to safeguard the fidelity of centriole duplication. Here, we overview past and present data discussing the regulation and functions of PLK4.

机译：Polo样激酶4（PLK4）是Polo样激酶家族的独特成员，与它的兄弟姐妹几乎没有同源性，并且在中心粒复制中起重要作用。必须严格控制该激酶的翻转，以防止中心粒扩增。这部分地通过自动调节机制来实现，其中PLK4使位于其催化结构域羧基末端的PEST序列中的残基自磷酸化。磷酸化的PLK4随后被SCF复合物识别，被泛素化并靶向蛋白酶体进行降解。最新数据还显示，活性PLK4限于中心体，该机制可用于防止细胞其他部位的异常中心体组装。尽管在了解如何调控PLK4方面已取得了重大进展，但可以肯定的是，还有其他的调控机制可以保护中心粒重复的保真度。在这里，我们概述了讨论PLK4调节和功能的过去和现在的数据。

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《Cell Division》 |2010年第1期|共页
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James E Sillibourne; Michel Bornens;
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中图分类细胞生物学;
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1. Polo-like kinase in trypanosomes: an odd member out of the Polo family [J] . Yasuhiro Kurasawa, Tai An, Ziyin Li Open Biology . 2020,第10期

机译：锥虫中的Polo样激酶：一个奇怪的成员从马球家族中
2. Polo-like kinase phosphorylation determines Caenorhabditis elegans centrosome size and density by biasing SPD-5 toward an assembly-competent conformation Polo-like kinase phosphorylation determines Caenorhabditis elegans centrosome size and density by biasing SPD-5 toward an assembly-competent conformation Polo-like kinase phosphorylation determines Caenorhabditis elegans centrosome size and density by biasing SPD-5 toward an assembly-competent conformation [J] . David Zwicker, Karen Oegema, Anthony A. Hyman, Biology Open . 2016,第10期

机译：Polo样激酶磷酸化通过将SPD-5偏向具有装配能力的构象来确定秀丽隐杆线虫中心体的大小和密度Polo样激酶磷酸化通过将SPD-5偏向具有装配能力的构象Polo样激酶来确定秀丽隐杆线虫中心体的大小和密度磷酸化通过将SPD-5偏向具有装配能力的构象来确定秀丽隐杆线虫中心体的大小和密度
3. Polo-like kinase phosphorylation determines Caenorhabditis elegans centrosome size and density by biasing SPD-5 toward an assembly-competent conformation Polo-like kinase phosphorylation determines Caenorhabditis elegans centrosome size and density by biasing SPD-5 toward an assembly-competent conformation Polo-like kinase phosphorylation determines Caenorhabditis elegans centrosome size and density by biasing SPD-5 toward an assembly-competent conformation [J] . David Zwicker, Karen Oegema, Anthony A. Hyman, Biology Open . 2016,第10期

机译：Polo样激酶磷酸化通过将SPD-5偏向具有装配能力的构象来确定秀丽隐杆线虫中心体的大小和密度Polo样激酶磷酸化通过将SPD-5偏向具有装配能力的构象Polo样激酶来确定秀丽隐杆线虫中心体的大小和密度磷酸化通过将SPD-5偏向具有装配能力的构象来确定秀丽隐杆线虫中心体的大小和密度
4. Mass Spectrometry Characterization of hCenexin1 Phosphorylation Vital to Polo-like Kinase 1 (Plk1) Interaction for Mitotic Functions [C] . Li-Rong Yu, Nak-Kyun Soung, Jung-Eun Park, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

机译：HCENEXIN1磷酸化至关重要的激酶1（PLK1）相互作用的质谱特征
5. Activity-dependent regulation of amyloid precursor protein (APP) by Polo-like kinase 2 (Plk2): Novel roles in synaptic plasticity. [D] . Lee, Ji Soo. 2016

机译：Polo样激酶2（Plk2）对淀粉样前体蛋白（APP）的活性依赖性调节：在突触可塑性中的新作用。
6. Polo-like kinase in trypanosomes: an odd member out of the Polo family [O] . Yasuhiro Kurasawa, Tai An, Ziyin Li 2020

机译：锥虫中的Polo样激酶：一个奇怪的成员从马球家族中
7. Polo-like kinase in trypanosomes: an odd member out of the Polo family [O] . Yasuhiro Kurasawa, Tai An, Ziyin Li 2020

机译：锥虫中的Polo样激酶：一个奇怪的成员从马球家族中

Polo-like kinase 4: the odd one out of the family

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