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首页> 外文期刊>Cellular Physiology and Biochemistry >Predictors of Lymph Node Metastasis and Prognosis in pT1 Colorectal Cancer Patients with Signet-Ring Cell and Mucinous Adenocarcinomas
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Predictors of Lymph Node Metastasis and Prognosis in pT1 Colorectal Cancer Patients with Signet-Ring Cell and Mucinous Adenocarcinomas

机译：pT1大肠癌伴印戒细胞和黏液腺癌的淋巴结转移和预后的预测因子。

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>Background/Aims: The local excision of early colorectal cancer is limited by the presence of lymph node metastasis (LNM). Signet-ring cell carcinomas (SRC) and mucinous adenocarcinomas (MAC) are two relatively infrequent histological subtypes. However, little is known about the predictors of LNM and prognosis to support the feasibility of local excision in early-stage SRC and MAC. Methods: The Surveillance Epidemiology and End Results Database were used to identify all patients with pT1 adenocarcinomas, including conventional adenocarcinoma (AC), MAC, and SRC. The prevalence of LNM was assessed, and the long-term survival rate in the above three types of colorectal cancer was calculated. Results: SRC accounted for 0.3% and MAC accounted for 4.4% of the entire cohort of colorectal adenocarcinomas. Compared to AC, MRC and SRC were more often located in the proximal colon, and exhibited a higher grade. The incidence of LNM in AC, MAC, and SRC was 10.6%, 17.2%, and 33.3% for colon cancers and 14.8%, 25.9%, and 46.2% for rectal cancers, respectively. In patients with lymph nodes resected no less than 12, incidence of LNM in AC, MRC, and SRC was 12%, 21%, and 44% for colon tumors and 17%, 30%, and 14% for rectal tumors, respectively. Although, colon patients MAC showed an entirely worse survival rate than AC, rectum patients MAC showed a similar prognosis to AC. We found that in patients with rectal tumors, SRC had a worse 3 and 5-year prognosis than AC. However, for colon cancers, the prognosis of SRC was similar to that of AC. Histology was not found to be an independent prognostic factor in multivariate survival analysis. Conclusions: MAC and SRC are two distinct subtypes of colorectal cancer that require special attention despite their relatively rare prevalence. pT1 patients with SRC of the rectum and patients with MAC of the colon have higher incidences of LNM, and with these adverse outcomes, local excision is not recommended. AlthoughMAC of the rectum and SRC of colon have a high rate of LNM, the prognosis of these types are similar to that of AC.
机译：> 背景/目标： 早期结直肠癌的局部切除受到淋巴结转移（LNM）的限制。印戒细胞癌（SRC）和粘液腺癌（MAC）是两种相对罕见的组织学亚型。但是，对于支持早期SRC和MAC的局部切除的可行性，关于LNM和预后的预测因素知之甚少。 方法： 使用监测流行病学和最终结果数据库来识别所有患有pT1腺癌的患者，包括常规腺癌（AC），MAC和SRC。评估LNM的患病率，并计算上述三种类型的结直肠癌的长期生存率。 结果： 在整个大肠腺癌队列中，SRC占0.3％，MAC占4.4％。与AC相比，MRC和SRC更常位于近端结肠中，并表现出较高的等级。在结肠癌中，AC，MAC和SRC中LNM的发生率分别为10.6％，17.2％和33.3％，对于直肠癌，分别为14.8％，25.9％和46.2％。切除淋巴结的患者不少于12，AC，MRC和SRC中LNM的发生率对于结肠肿瘤分别为12％，21％和44％，对于直肠肿瘤分别为17％，30％和14％。尽管结肠癌患者MAC的生存率比AC患者差，但是直肠癌患者MAC的预后与AC患者相似。我们发现在患有直肠肿瘤的患者中，SRC的3年和5年预后比AC更差。但是，对于结肠癌，SRC的预后与AC相似。在多变量生存分析中，组织学未发现是独立的预后因素。 结论： MAC和SRC是结直肠癌的两种截然不同的亚型，尽管它们的患病率相对较低，但仍需要特别注意。 pT1的直肠SRC患者和结肠的MAC患者的LNM发生率较高，并且由于这些不良后果，不建议局部切除。尽管直肠MAC和结肠SRC具有较高的LNM发生率，但这些类型的预后与AC相似。

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