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首页> 外文期刊>Ceylon Medical Journal >Validation of the Sinhala version of the Chronic Liver Disease Questionnaire (CLDQ) for assessment of health related quality of life among Sri Lankan cirrhotics
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Validation of the Sinhala version of the Chronic Liver Disease Questionnaire (CLDQ) for assessment of health related quality of life among Sri Lankan cirrhotics

机译：僧伽罗语版慢性肝病问卷（CLDQ）的验证，用于评估斯里兰卡肝硬化患者的健康相关生活质量

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Objectives The Chronic Liver Disease Questionnaire (CLDQ) is a validated tool measuring Health Related Quality of Life among patients with cirrhosis. The aim of this study was to validate a Sinhala version of the CLDQ (sCLDQ) and to test its correlation with the degree of liver dysfunction in a cohort of Sri Lankan patients with cirrhosis. Methods A standard translation method was used. Pilot testing was done with relevant cultural and language adaptations. The final version and the WHO Quality of Life-BREF (WHOQOL-BREF) validated Sinhala version were administered to patients with chronic lever disease (CLD). sCLDQ was re-administered 4 weeks later to test internal consistency and reliability. The validaty and reliability were assessed by Cronabach’s alpha, intraclass correlation coefficient (ICC) and Pearson's correlation coefficient. ANOVA and Pearson's correlation were used to assess correlation with the degree of liver dysfunction. Results Validation was done with 214 participants [mean age 55.6 years (SD 10.4) male 77.6%]. Cronabach’s alpha was 0.926. Intra-class correlations varied from 0.431 to 0.912 and all were significant (p< 0.001). Retesting was done on a sub-sample of 18 participants. Test-retest correlation was 0.695 (p = 0.008). WHO-BREF was administered to a sub-sample of 48 subjects. There was a significant correlation (Pearson’s r=0.391; p=0.004) between sCLDQ and WHOQOL BREF. sCLDQ was significantly associated with MELD (r=-0.13; p=0.038), MELD sodium (r=-0.223; p=0.002), serum bilirubin (r=-0.124; p=0.036), serum sodium (r=0.172; p=0.009), serum albumin (r=0.201; p=0.003) and Child grade (f=3.687; p=0.027). Conclusions CLDQ is a reliable and valid tool to assess quality of life of Sri Lankan patients with cirrhosis and correlates well with known indices of disease severity. DOI: http://dx.doi.org/10.4038/cmj.v58i4.5612 Ceylon Medical Journal 2013; 58: 156-162
机译：目的慢性肝病问卷（CLDQ）是一种经过验证的工具，可测量肝硬化患者的健康相关生活质量。这项研究的目的是验证Sinhala版本的CLDQ（sCLDQ），并测试其与斯里兰卡肝硬化患者队列中肝功能障碍程度的相关性。方法采用标准翻译方法。进行了相关文化和语言适应性的试点测试。最终版本和经世卫组织生活质量BREF（WHOQOL-BREF）验证的僧伽罗语版本已施用于患有慢性杠杆病（CLD）的患者。 sCLDQ在4周后重新使用，以测试内部一致性和可靠性。通过Cronabach的alpha，组内相关系数（ICC）和Pearson相关系数评估有效性和可靠性。方差分析和皮尔逊相关性用于评估与肝功能障碍程度的相关性。结果对214名参与者进行了验证[平均年龄55.6岁（SD 10.4）男性77.6％，％]。克罗纳巴赫的alpha为0.926。类内相关性从0.431到0.912不等，并且都具有显着性（p <0.001）。对18名参与者的子样本进行了重新测试。重测相关系数为0.695（p = 0.008）。对48个受试者的子样本进行了WHO-BREF的管理。 sCLDQ与WHOQOL BREF之间存在显着的相关性（Pearson r = 0.391; p = 0.004）。 sCLDQ与MELD（r = -0.13; p = 0.038），MELD钠（r = -0.223; p = 0.002），血清胆红素（r = -0.124; p = 0.036），血清钠（r = 0.172; p = 0.009），血清白蛋白（r = 0.201; p = 0.003）和儿童等级（f = 3.687; p = 0.027）。结论CLDQ是评估斯里兰卡肝硬化患者生活质量的可靠且有效的工具，并且与已知的疾病严重性指标密切相关。 DOI：http：//dx.doi.org/10.4038/cmj.v58i4.5612锡兰医学杂志2013; 58：156-162

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