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首页> 外文期刊>Cases Journal >A multicentric, hyaline vascular variant of Castleman's disease associated with B cell lymphoma: a case report
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A multicentric, hyaline vascular variant of Castleman's disease associated with B cell lymphoma: a case report

机译：与B细胞淋巴瘤相关的Castleman病的多中心，透明血管变种：病例报告

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Introduction Three histological variants (hyaline vascular, plasma cell, and mixed) and two clinical types (localized and multicentric) of Castleman's disease have been described. The risk of progression to lymphoma is higher in multicentric Castleman's disease and is associated with poorer outcomes and higher mortality rate. Multicentric Castleman's disease often requires systemic therapy. Complete resection of the involved node in localized Castleman's disease is curative, with no reported recurrences. Case presentation We report a case of a 66-year-old female with systemic symptoms and bilateral cervical lymph nodes which were initially diagnosed as the hyaline vascular variant of Castleman's disease and two years later after the initial diagnosis she was confirmed to B cell lymphoma. Following the treatment with radiation therapy to the cervical area and combination chemotherapy complete response was achieved. Conclusion Although it has rarely been reported, the malignant potential of the Castleman's disease must be kept in mind.
机译：引言已经描述了Castleman病的三种组织学变异（透明血管，浆细胞和混合）和两种临床类型（局部和多中心）。在多中心Castleman病中，发展为淋巴瘤的风险较高，并且与不良预后和较高的死亡率相关。多中心Castleman病通常需要全身治疗。局部切除Castleman病可完全切除受累结节，目前尚无复发的报道。病例介绍我们报告了一例66岁的女性，该女性具有全身症状和双侧颈淋巴结转移，最初被诊断为Castleman病的透明血管变异，两年后的初步诊断被确诊为B细胞淋巴瘤。在对颈部区域进行放射治疗和联合化疗后，达到了完全缓解。结论尽管鲜有报道，但必须牢记卡斯曼病的恶性潜能。

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