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Self-Management of Oxaliplatin-Related Peripheral Neuropathy in Colorectal Cancer Survivors

机译：大肠癌幸存者中奥沙利铂相关周围神经病变的自我管理

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Purpose. The purpose of this study was to evaluate medications that cancer survivors with oxaliplatin-induced peripheral neuropathy take to control neuropathic symptom, and to explore self-management techniques used at home to provide temporary relief of painful neuropathy. This was a mixed methods, descriptive, cross-sectional study using self-reported data from colorectal cancer survivors previously treated with oxaliplatin. We analyzed demographic and medication data obtained from participants, along with written comments from an open-ended question regarding methods participants had tried to self-manage symptoms of neuropathy.Results. Twenty-nine percent of the sample reported taking some type of nutritional supplement with potential neuroprotective qualities. Opioids were being taken by 10% of the sample, and nonsteroidal anti-inflammatory and over-the-counter medications were taken by 15% of participants. Twelve percent of participants were taking antidepressants and 10% were taking anticonvulsants, primarily gabapentin. Recurrent themes for nonpharmacologic treatment included avoiding the cold/keeping warm, keeping moving, massaging or rubbing the affected area, and living with it.Conclusions. Patients treated with oxaliplatin for colorectal cancer utilize a variety of traditional pharmacologic agents and nutritional supplements in an effort to self-manage neuropathic symptoms. Patients also employ a variety of home-based therapies to provide temporary relief of peripheral neuropathy symptoms.
机译：目的。这项研究的目的是评估患有奥沙利铂诱导的周围神经病的癌症幸存者可以用来控制神经病症状的药物，并探索在家中用于自我缓解疼痛神经病的自我管理技术。这是一项混合方法，描述性，横断面研究，使用来自先前用奥沙利铂治疗的结直肠癌幸存者的自我报告数据。我们分析了从参与者获得的人口统计学和药物治疗数据，以及关于参与者试图自我管理神经病变症状的方法的一个开放式问题的书面评论。有29％的样品报告服用了某种具有潜在神经保护作用的营养补品。阿片类药物占10％，非类固醇消炎药和非处方药占15％。百分之十二的参与者正在服用抗抑郁药，百分之十的参与者正在服用抗惊厥药，主要是加巴喷丁。非药物治疗的经常性主题包括避免受凉/保暖，保持活动，按摩或摩擦患处以及与患处生活。用奥沙利铂治疗结直肠癌的患者利用多种传统药物和营养补品来自我管理神经性症状。患者还采用各种家庭疗法，以暂时缓解周围神经病症状。

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