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首页> 外文期刊>Circulation journal >Diagnosis and Assessment of Takayasu Arteritis by Multiple Biomarkers
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Diagnosis and Assessment of Takayasu Arteritis by Multiple Biomarkers

机译：多发性生物标志物诊断和评估高隆动脉炎

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Background: ?Patients with Takayasu arteritis (TA) often show recurrence under steroid treatment without an elevation of C-reactive protein (CRP). There is a report that matrix metalloproteinase (MMP)-2, MMP-3, MMP-9 and pentraxin3 (PTX3) could be sensitive biomarkers, but the characteristics of these biomarkers have not been established. Methods and Results: ?We enrolled 45 consecutive patients; 28 were grouped in an active phase as evidenced by clinical recurrence within 2 years of blood sampling. Circulating levels of high-sensitivity (hs)CRP, MMPs, and PTX3 were determined. Patients in an active phase showed higher levels of hsCRP, MMP-9, and PTX3. Area under the receiving operating characteristics curves of hsCRP and PTX3 were significantly higher than that of MMP-9. Among the 28 patients with active TA, 71% was positive for hsCRP and 82% for PTX3. Patients without recurrence showed significantly higher plasma levels of MMP-9. There was a positive correlation between the plasma MMP-3 level and the prednisolone dose. However, PTX3 and MMP-9 levels did not have such a correlation. Conclusions: ?PTX3 and MMP-9, which are not affected by prednisolone, could be sensitive biomarkers for assessing TA activity. Evaluation of MMP-9 may suggest prior existence of TA.??(Circ J?2013; 77: 477–483)
机译：背景：高固动脉炎（TA）的患者在类固醇治疗下通常会复发，而C反应蛋白（CRP）不会升高。有报道称基质金属蛋白酶（MMP）-2，MMP-3，MMP-9和pentraxin3（PTX3）可能是敏感的生物标志物，但尚未确定这些生物标志物的特征。方法和结果：我们连续入选了45例患者。血液采样2年内临床复发证明28处于活跃期。确定了高敏感性（hs）CRP，MMP和PTX3的循环水平。处于活动期的患者表现出较高水平的hsCRP，MMP-9和PTX3。 hsCRP和PTX3的接受操作特性曲线下的面积显着高于MMP-9。在28名活动性TA患者中，hsCRP阳性71％，PTX3阳性82％。没有复发的患者表现出明显更高的血浆MMP-9水平。血浆MMP-3水平与泼尼松龙剂量呈正相关。但是，PTX3和MMP-9水平没有这种相关性。结论：不受强的松龙影响的？PTX3和MMP-9可能是评估TA活性的敏感生物标志物。 MMP-9的评估可能暗示了TA的存在。（Circ J？2013; 77：477–483）

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