• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinics >Osteosarcoma of the jaw – experience at the Medical University Vienna and comparative study with international tumor registries
【24h】

Osteosarcoma of the jaw – experience at the Medical University Vienna and comparative study with international tumor registries

机译：颌骨肉瘤–维也纳医科大学的经验以及与国际肿瘤注册机构的比较研究

获取原文
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVES: Osteosarcoma of the jaw (OSAJ) is fundamentally different in clinical practice from its peripheral counterparts. Studies are difficult to conduct due to low incidence rates. The primary aim of this study was to provide for the first time a comprehensive retrospective analysis of the treatment concepts and outcome data of OSAJ patients treated at the University Hospital Vienna and to compare these with two recently published studies on OSAJ. The clinical study was accompanied by a biomarker study investigating the prognostic relevance of melanoma-associated antigen-A (MAGE-A) in OSAJ specimens. METHOD: Eighteen patients were included, and their outcomes were compared to published data. Immunohistochemistry was performed with mouse monoclonal antibodies against MAGE-A. Survival rates were estimated by the Kaplan-Meyer method. The log-rank test was used to analyze potential prognostic parameters. Fisher’s exact test was performed to define the significant differences between the survival rates of the current study and the DOESAK registry. RESULTS: Disease-specific survival was 93.8% after five and 56.3% after ten years. The development of metastases ( p =0.033) or relapse ( p =0.037) was associated with worsened outcomes in our group as well as in the comparative group. Despite the different treatment concepts of the study groups, survival rates were comparable. MAGE-A failed to show prognostic relevance for OSAJ patients. CONCLUSIONS: Uncertainties about the optimal treatment strategies of OSAJ patients will currently remain. Thus, prospective studies of OSAJ are needed but are only feasible in a multicenter study setting, conducted over a prolonged time period.
机译：目的：颌骨骨肉瘤（OSAJ）在临床实践中与周围的骨肉瘤有根本不同。由于发生率低，很难进行研究。这项研究的主要目的是首次对在维也纳大学医院接受治疗的OSAJ患者的治疗概念和结果数据进行全面的回顾性分析，并将其与最近发表的两项OSAJ研究进行比较。临床研究伴随着一项生物标志物研究，该研究研究了OSAJ标本中黑色素瘤相关抗原A（MAGE-A）的预后相关性。方法：纳入18例患者，并将其结果与已发表的数据进行比较。用抗MAGE-A的小鼠单克隆抗体进行免疫组织化学。生存率通过Kaplan-Meyer方法估算。使用对数秩检验来分析潜在的预后参数。进行了Fisher精确测试，以定义当前研究与DOESAK注册中心的生存率之间的显着差异。结果：五年后疾病特异性存活率为93.8％，十年后为56.3％。转移的发生（p = 0.033）或复发（p = 0.037）与我们组和比较组的预后恶化有关。尽管研究组的治疗概念不同，但存活率是可比的。 MAGE-A未能显示出对OSAJ患者的预后相关性。结论：目前仍存在关于OSAJ患者最佳治疗策略的不确定性。因此，需要对OSAJ进行前瞻性研究，但仅在长时间进行的多中心研究环境中可行。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号