Altered Sleep Patterns and Physiologic Characteristics in Spontaneous Dwarf Rats

Andersen Monica L; Lee Kil S; Guindalini Camila; Leite Waldemarks A; Bignotto Magda; Tufik Sergio

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Altered Sleep Patterns and Physiologic Characteristics in Spontaneous Dwarf Rats

机译：自发性矮小大鼠睡眠模式和生理特征的改变

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Spontaneousdwarfratsareausefulexperimentalmodelforstudyingvariousbiologiceventsassociatedwithpituitarydwarfism.DwarfratsoccurredserendipitouslyinourcolonyofWistarratsduringexperimentalbreeding.Thisstudyaimedtodescribethesleeppatternandphysiologiccharacteristicsoftheseratscomparedwithnormal-sizedadultrats.Becausegrowthhormonecanattenuatetheupregulationofceruloplasminexpressioncausedbyacuteinflammation,wealsoassessedthebasallevelsofserumceruloplasminintheseanimals.At90dofage,bodyweightandlengthweresignificantlylowerindwarfratsrelativetonormalrats.Dwarveshadlowerconcentrationsofserumtestosteroneandgrowthhormone,butprogesteronewasunchanged.Corticosteronelevelsdidnotdifferbetweengroups.Duringthelightperiod,thepercentageofsleeptimerecordedanddurationofslow-wavesleepdidnotdifferbetweengroups.However,comparedwithcontrols,dwarfratshadmarkedfragmentationofsleepandlessparadoxicalsleep.Duringthedarkphase,sleeppatternsindwarfratswerewithinthenormalrange.Immunoblottingdatashowedthatthelevelsofceruloplasmininserumwerelowerindwarfrats.Ourfindingsprovideinsightintopathologicprocessesrelatedtogrowthhormonedeficiency.

机译：Spontaneousdwarfratsareausefulexperimentalmodelforstudyingvariousbiologiceventsassociatedwithpituitarydwarfism.DwarfratsoccurredserendipitouslyinourcolonyofWistarratsduringexperimentalbreeding.Thisstudyaimedtodescribethesleeppatternandphysiologiccharacteristicsoftheseratscomparedwithnormal-sizedadultrats.Becausegrowthhormonecanattenuatetheupregulationofceruloplasminexpressioncausedbyacuteinflammation，wealsoassessedthebasallevelsofserumceruloplasminintheseanimals.At90dofage，bodyweightandlengthweresignificantlylowerindwarfratsrelativetonormalrats.Dwarveshadlowerconcentrationsofserumtestosteroneandgrowthhormone，butprogesteronewasunchanged.Corticosteronelevelsdidnotdifferbetweengroups.Duringthelightperiod，thepercentageofsleeptimerecordedanddurationofslow-wavesleepdidnotdifferbetweengroups.However，comparedwithcontrols，dwarfratshadmarkedfragmentationofsleepandlessparadoxicalsleep.Duringthedarkphase，sleeppatternsindwarfratswerewithinthenormalrange.Immunoblottingdatashowedthatthelevelsofcerulo我们的发现提供了与生长激素缺乏相关的病理过程的洞察力。

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《Comparative Medicine》 |2009年第4期|共页
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Andersen Monica L; Lee Kil S; Guindalini Camila; Leite Waldemarks A; Bignotto Magda; Tufik Sergio;
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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6. Altered Sleep Patterns and Physiologic Characteristics in Spontaneous Dwarf Rats [O] . Monica L Andersen, Kil S Lee, Camila Guindalini, 2009

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Altered Sleep Patterns and Physiologic Characteristics in Spontaneous Dwarf Rats

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