Altered sleep patterns and physiologic characteristics in spontaneous dwarf rats

Andersen ML; Lee KS; Guindalini C; Leite WA; Bignotto M; Tufik S

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Altered sleep patterns and physiologic characteristics in spontaneous dwarf rats

机译：自发性侏儒大鼠的睡眠方式和生理特征改变

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Spontaneous dwarf rats are a useful experimental model for studying various biologic events associated with pituitary dwarfism. Dwarf rats occurred serendipitously in our colony of Wistar rats during experimental breeding. This study aimed to describe the sleep pattern and physiologic characteristics of these rats compared with normal-sized adult rats. Because growth hormone can attenuate the upregulation of ceruloplasmin expression caused by acute inflammation, we also assessed the basal levels of serum ceruloplasmin in these animals. At 90 d of age, body weight and length were significantly lower in dwarf rats relative to normal rats. Dwarves had lower concentrations of serum testosterone and growth hormone, but progesterone was unchanged. Corticosterone levels did not differ between groups. During the light period, the percentage of sleep time recorded and duration of slow-wave sleep did not differ between groups. However, compared with controls, dwarf rats had marked fragmentation of sleep and less paradoxical sleep. During the dark phase, sleep patterns in dwarf rats were within the normal range. Immunoblotting data showed that the levels of ceruloplasmin in serum were lower in dwarf rats. Our findings provide insight into pathologic processes related to growth hormone deficiency.

机译：自发性侏儒大鼠是有用的实验模型，用于研究与垂体侏儒症相关的各种生物学事件。在实验繁殖期间，矮人鼠偶然出现在我们的Wistar鼠群落中。这项研究旨在描述与正常大小的成年大鼠相比，这些大鼠的睡眠方式和生理特征。因为生长激素可以减轻由急性炎症引起的铜蓝蛋白表达的上调，所以我们还评估了这些动物中血清铜蓝蛋白的基础水平。与正常大鼠相比，矮人大鼠在90 d时的体重和身长显着降低。矮人的血清睾丸激素和生长激素的浓度较低，但孕酮未改变。两组之间的皮质酮水平没有差异。在光亮时期，两组之间记录的睡眠时间百分比和慢波睡眠持续时间没有差异。然而，与对照组相比，侏儒大鼠的睡眠明显分散，反常睡眠较少。在黑暗阶段，侏儒大鼠的睡眠模式在正常范围内。免疫印迹数据显示，侏儒大鼠血清中的铜蓝蛋白水平较低。我们的发现提供了与生长激素缺乏症相关的病理过程的见解。

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《Comparative Medicine》 |2009年第4期|共6页
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Andersen ML; Lee KS; Guindalini C; Leite WA; Bignotto M; Tufik S;
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1. Altered sleep patterns and physiologic characteristics in spontaneous dwarf rats [J] . Andersen ML, Lee KS, Guindalini C, Comparative Medicine . 2009,第4期

机译：自发性侏儒大鼠的睡眠方式和生理特征改变
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Altered sleep patterns and physiologic characteristics in spontaneous dwarf rats

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