Experimental Infection of Mice with Hamster Parvovirus: Evidence for Interspecies Transmission of Mouse Parvovirus 3

Christie; Rachel D; nbsp; Marcus; Emily C; nbsp; Wagner; April M; nbsp; Besselsen; David G

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Experimental Infection of Mice with Hamster Parvovirus: Evidence for Interspecies Transmission of Mouse Parvovirus 3

机译：仓鼠细小病毒对小鼠的实验感染：小鼠细小病毒3种间传播的证据。

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Hamsterparvovirus(HaPV)wasisolated2decadesagofromhamsterswithclinicalsignssimilartothoseinducedinhamstersexperimentallyinfectedwithotherrodentparvoviruses.Genetically,HaPVismostcloselyrelatedtomouseparvovirus(MPV),whichinducessubclinicalinfectioninmice.AnovelMPVstrain,MPV3,wasdetectedrecentlyinnaturallyinfectedmice,andgenomicsequenceanalysisindicatesthatMPV3isalmostidenticaltoHaPV.ThegoalofthepresentstudieswastoexaminetheinfectivityofHaPVinmice.NeonatalandweanlingmiceofseveralmousestrainswereinoculatedwithHaPV.Tissues,excretions,andserawereharvestedat1,2,4,and8wkafterinoculationandevaluatedbyquantitativePCRandserologicassaysspecificforHaPV.QuantitativePCRdetectedviralDNAquantitiesthatgreatlyexceededthequantityofvirusininoculainmultipletissuesofinfectedmice.Seroconversiontobothnonstructuralandstructuralviralproteinswasdetectedinmostimmunocompetentmice2ormoreweeksafterinoculationwithHaPV.InneonatalSCIDmice,viraltranscriptsweredetectedinlymphoidtissuesbyRT-PCRandviralDNAwasdetectedinfecesbyquantitativePCRat8wkafterinoculation.Noclinicalsigns,gross,orhistologiclesionswereobserved.ThesefindingsaresimilartothoseobservedinmiceinfectedwithMPV.ThesedatasupportthehypothesisthatHaPVandMPV3arelikelyvariantsofthesameviralspecies,forwhichthemouseisthenaturalrodenthostwithrareinterspeciestransmissiontothehamster.

机译：Hamsterparvovirus（HaPV）wasisolated2decadesagofromhamsterswithclinicalsignssimilartothoseinducedinhamstersexperimentallyinfectedwithotherrodentparvoviruses.Genetically，HaPVismostcloselyrelatedtomouseparvovirus（MPV），whichinducessubclinicalinfectioninmice.AnovelMPVstrain，MPV3，wasdetectedrecentlyinnaturallyinfectedmice，andgenomicsequenceanalysisindicatesthatMPV3isalmostidenticaltoHaPV.ThegoalofthepresentstudieswastoexaminetheinfectivityofHaPVinmice.NeonatalandweanlingmiceofseveralmousestrainswereinoculatedwithHaPV.Tissues，排泄物，andserawereharvestedat1,2,4，and8wkafterinoculationandevaluatedbyquantitativePCRandserologicassaysspecificforHaPV.QuantitativePCRdetectedviralDNAquantitiesthatgreatlyexceededthequantityofvirusininoculainmultipletissuesofinfectedmice.Seroconversiontobothnonstructuralandstructuralviralproteinswasdetectedinmostimmunocompetentmice2ormoreweeksafterinoculationwithHaPV.InneonatalSCIDmice，viraltranscriptsweredetectedinlymphoidtissuesbyRT-PCRandviralDNAwasdetectedinfeces接种后第8周通过定量PCR观察到临床症状，毛病或组织学病变。这些发现与被MPV感染的小鼠相似。这些数据支持一个假设，即HAPV和MPV3可能是变异的，柔软的同种病毒，其宿主之间的互斥是天然的。

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《Comparative Medicine》 |2010年第2期|共页
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Christie; Rachel D; nbsp; Marcus; Emily C; nbsp; Wagner; April M; nbsp; Besselsen; David G;
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Experimental Infection of Mice with Hamster Parvovirus: Evidence for Interspecies Transmission of Mouse Parvovirus 3 [J] . Christie Rachel D., Marcus Emily C., Wagner April M., Comparative Medicine . 2010,第2期

机译：仓鼠细小病毒对小鼠的实验感染：小鼠细小病毒3种间传播的证据。
2. Natural and Experimentally Induced Infection of Syrian Hamsters with a Newly Recognized Parvovirus [J] . Comparative Medicine . 1999,第3期

机译：自然和实验诱导的叙利亚仓鼠感染新发现的细小病毒
3. Natural and experimentally induced infection of Syrian hamsters with a newly recognized parvovirus. [J] . Besselsen DG, Gibson SV, Besch Williford CL, Laboratory Animal Science . 1999,第3期

机译：自然和实验诱导的叙利亚仓鼠感染新识别的细小病毒。
4. The High Risk of Human Parvovirus B19 Infection in Patients with Malignant Tumors [C] . Li Yasha, Dong Yanming, Xu Guopeng, 5th International Conference on Bioinformatics and Biomedical Engineering . 2011

机译：恶性肿瘤患者中人类细小病毒B19感染的高风险
5. Construction and characterization of a chimeric clone of parvovirus LuIII containing a substitution of its genomic termini for those of the prototype strain of parvovirus mice minute virus. [D] . Acevedo-Suarez, Carlos A. 2000

机译：细小病毒LuIII嵌合克隆的构建和表征，该细克隆包含其基因组末端被细小病毒小鼠微小病毒的原型菌株所取代。
6. Experimental Infection of Mice with Hamster Parvovirus: Evidence for Interspecies Transmission of Mouse Parvovirus 3 [O] . Rachel D Christie, Emily C Marcus, April M Wagner, 2010

机译：仓鼠细小病毒对小鼠的实验感染：小鼠细小病毒3种间传播的证据。
7. Multiplex polymerase chain reaction assay for the detection of minute virus of mice and mouse parvovirus infections in laboratory mice [O] . Wang, KW 2013

机译：多重聚合酶链反应分析法检测小鼠微小病毒和小鼠细小病毒感染

Experimental Infection of Mice with Hamster Parvovirus: Evidence for Interspecies Transmission of Mouse Parvovirus 3

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