Helicobacter Infection Decreases Reproductive Performance of IL10-deficient Mice

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Helicobacter Infection Decreases Reproductive Performance of IL10-deficient Mice

机译：幽门螺杆菌感染会降低缺乏IL10的小鼠的繁殖能力

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InfectionswithavarietyofHelicobacterspecieshavebeendocumentedinrodentresearchfacilities,withvariableeffectsonrodenthealth.HelicobactertyphloniushasbeenreportedtocauseentericdiseaseinimmunodeficientandIL10supxmlns="http://pub2web.metastore.ingenta.coms/"-/-/supmice,whereasH.rodentiumhasonlybeenreportedtocausediseaseinimmunodeficientmicecoinfectedwithotherHelicobacterspecies.TheeffectofHelicobacterinfectionsonmurinereproductionhasnotbeenwellstudied.ThereproductiveperformanceofC57BL/6IL10supxmlns="http://pub2web.metastore.ingenta.coms/"-/-/supfemalemiceintentionallyinfectedwithH.typhlonius,H.rodentium,orbothwascomparedwiththatofage-matcheduninfectedcontrolsorsimilarlyinfectedmicethatreceivedantihelicobactertherapy.ThepresenceofHelicobacterorganismsinstoolandrelevanttissueswasdetectedbyPCRassays.HelicobacterinfectionofIL10supxmlns="http://pub2web.metastore.ingenta.coms/"-/-/supfemalemicemarkedlydecreasedpregnancyratesandpupsurvival.ThenumberofpupssurvivingtoweaningwasgreatestinnoninfectedmiceanddecreasedforH.rodentiumH.typhloniusH.rodentiumandH.typhloniuscoinfectedmice.Helicobacterorganismsweredetectedbysemiquantitativereal-timePCRinthereproductiveorgansofasubsetofinfectedmice.Treatmentofinfectedmicewitha4-drugregimenconsistingofamoxicillin,clarithromycin,metronidazole,andomeprazoleincreasedpregnancyrates,andpupsurvivalanddamfecundityimproved.WeconcludethatinfectionwithH.typhlonius,H.rodentium,orbothdecreasedthereproductiveperformanceofIL10supxmlns="http://pub2web.metastore.ingenta.coms/"-/-/supmice.Inaddition,antihelicobactertherapyimprovedfecundityandenhancedpupsurvival.

机译：InfectionswithavarietyofHelicobacterspecieshavebeendocumentedinrodentresearchfacilities，withvariableeffectsonrodenthealth.HelicobactertyphloniushasbeenreportedtocauseentericdiseaseinimmunodeficientandIL10 - / - 小鼠，whereasH.rodentiumhasonlybeenreportedtocausediseaseinimmunodeficientmicecoinfectedwithotherHelicobacterspecies.TheeffectofHelicobacterinfectionsonmurinereproductionhasnotbeenwellstudied.ThereproductiveperformanceofC57BL / 6IL10 -/-女性小鼠故意感染了H.typhlonius，H.rodentium，或两者均与年龄相匹配的未感染的对照或通过ELISA检测到的幽门螺杆菌在细菌中的结合。 / ns /“>-/-雌性小鼠的妊娠率和幼仔存活率明显下降。 testinnoninfectedmiceanddecreasedforH.rodentium> H.typhlonius H.rodentiumandH.typhloniuscoinfectedmice.Helicobacterorganismsweredetectedbysemiquantitativereal-timePCRinthereproductiveorgansofasubsetofinfectedmice.Treatmentofinfectedmicewitha4-drugregimenconsistingofamoxicillin，克拉霉素，甲硝唑，andomeprazoleincreasedpregnancyrates，andpupsurvivalanddamfecundityimproved.WeconcludethatinfectionwithH.typhlonius，H.rodentium，orbothdecreasedthereproductiveperformanceofIL10

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《Comparative Medicine》 |2008年第5期|共页
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Helicobacter infection decreases reproductive performance of IL10-deficient mice [J] . Sharp JM, Vanderford DA, Chichlowski M, Comparative Medicine . 2008,第5期

机译：幽门螺杆菌感染会降低IL10缺陷小鼠的生殖能力
2. Helicobacter typhlonius and Helicobacter rodentium Differentially Affect the Severity of Colon Inflammation and Inflammation-Associated Neoplasia in IL10-Deficient Mice [J] . Chichlowski Maciej, Sharp Julie M., Vanderford Deborah A., Comparative Medicine . 2008,第6期

机译：Typhlonius幽门螺杆菌和啮齿类幽门螺杆菌差异影响IL10缺陷小鼠结肠炎症和炎症相关肿瘤的严重程度
3. Helicobacter typhlonius and Helicobacter rodentium Differentially Affect the Severity of Colon Inflammation and Inflammation-Associated Neoplasia in IL10-Deficient Mice [J] . Chichlowski Maciej, Sharp Julie M, Vanderford Deborah A, Comparative Medicine . 2008,第6期

机译：Typhlonius幽门螺杆菌和啮齿类幽门螺杆菌差异影响IL10缺陷小鼠结肠炎症和炎症相关肿瘤的严重程度
4. Chitosan microspheres can fight Helicobacter pylori gastric infection in mice [C] . Patricia C Henriques, Lia M Costa, Susana Junqueira-Neto, World biomaterials congress . 2016

机译：壳聚糖微球可抵抗小鼠幽门螺杆菌胃感染
5. Modeling human immunodeficiency virus-1 (HIV-1) infection in the male reproductive tract (MRT) using humanized mice [D] . Fisher, Suhrim. 2016

机译：使用人源化小鼠模拟男性生殖道（MRT）中的人类免疫缺陷病毒1（HIV-1）感染
6. Helicobacter Infection Decreases Reproductive Performance of IL10-deficient Mice [O] . Julie M Sharp, Deborah A Vanderford, Maciej Chichlowski, 2008

机译：幽门螺杆菌感染会降低IL10缺陷小鼠的生殖能力
7. Orally administrated chitosan microspheres bind Helicobacter pylori and decrease gastric infection in mice [O] . Patrícia C. Henriques, Lia M. Costa, Catarina L. Seabra, 2020

机译：口服给予的壳聚糖微球结合幽门螺杆菌并降低小鼠胃感染

Helicobacter Infection Decreases Reproductive Performance of IL10-deficient Mice

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