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Cystic Mammary Adenocarcinoma Associated with a Prolactin-secreting Pituitary Adenoma in a New Zealand White Rabbit (Oryctolagus cuniculus)

机译:囊性乳腺腺癌与分泌性催乳素的垂体腺瘤相关的新西兰白兔(穴兔)

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A44-mo-old,female,nulliparousNewZealandWhiteRabbit(Oryctolaguscuniculuspresentedwithbilaterallydiffuselyenlargedmammaryglandswithenlarged,discoloredteatsthatexudedbrown,mucoiddischarge.Thecompletebloodcountandserumchemistrypanelswerewithinnormallimits,bacteriawerenotisolatedfromacultureofthedischarge,andtheclinicalsignsdidnotresolvewithantibiotictreatment.Computedtomographyandserumprolactinlevelssupportedthediagnosisofmammaryglanddysplasia,possiblyduetoaprolactin-secretingpituitaryadenoma.Histologicevaluationconfirmedthepresenceofapituitaryadenoma,mammaryhyperplasia,dysplasia,andcysticmammaryadenocarcinoma.Immunohistochemicalstainingconfirmedthepresenceofabundantprolactinsecretingcellsinthepituitaryadenoma.Thisisthesecondreportofhyperprolactinemiawithmammarydysplasiainrabbits,andthefirstreportofcysticmammaryadenocarcinomaassociatedwithaprolactin-secretingpituitaryadenomainarabbit.
机译:A44-月大,雌性,nulliparousNewZealandWhiteRabbit(Oryctolaguscuniculuspresentedwithbilaterallydiffuselyenlargedmammaryglandswithenlarged,discoloredteatsthatexudedbrown,mucoiddischarge.Thecompletebloodcountandserumchemistrypanelswerewithinnormallimits,bacteriawerenotisolatedfromacultureofthedischarge,andtheclinicalsignsdidnotresolvewithantibiotictreatment.Computedtomographyandserumprolactinlevelssupportedthediagnosisofmammaryglanddysplasia,possiblyduetoaprolactin-secretingpituitaryadenoma.Histologicevaluationconfirmedthepresenceofapituitaryadenoma,mammaryhyperplasia,发育不良,andcysticmammaryadenocarcinoma.Immunohistochemicalstainingconfirmedthepresenceofabundantprolactinsecretingcellsinthepituitaryadenoma.Thisisthesecondreportofhyperprolactinemiawithmammarydysplasiainrabbits,andthefirstreportofcysticmammaryadenocarcinomaassociatedwithaprolactin-secretingpituitaryadenomainarabbit。

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