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首页> 外文期刊>Comparative Medicine >Cystic Mammary Adenocarcinoma Associated with a Prolactin-secreting Pituitary Adenoma in a New Zealand White Rabbit (Oryctolagus cuniculus).
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Cystic Mammary Adenocarcinoma Associated with a Prolactin-secreting Pituitary Adenoma in a New Zealand White Rabbit (Oryctolagus cuniculus).

机译：囊性乳腺腺癌与分泌性催乳素的垂体腺瘤相关的新西兰白兔（Oryctolagus cuniculus）。

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摘要

A 44-mo-old, female, nulliparous New Zealand White Rabbit (Oryctolagus cuniculus) presented with bilaterally diffusely enlarged mammary glands with enlarged, discolored teats that exuded brown, mucoid discharge. The complete blood count and serum chemistry panels were within normal limits, bacteria were not isolated from a culture of the discharge, and the clinical signs did not resolve with antibiotic treatment. Computed tomography and serum prolactin levels supported the diagnosis of mammary gland dysplasia, possibly due to a prolactin-secreting pituitary adenoma. Histologic evaluation confirmed the presence of a pituitary adenoma, mammary hyperplasia, dysplasia, and cystic mammary adenocarcinoma. Immunohistochemical staining confirmed the presence of abundant prolactin secreting cells in the pituitary adenoma. This is the second report of hyperprolactinemia with mammary dysplasia in rabbits, and the first report of cystic mammary adenocarcinoma associated with a prolactin-secreting pituitary adenoma in a rabbit.
机译：一只44岁大的雌性不育新西兰白兔（Oryctolagus cuniculus）表现为双侧乳腺弥漫性扩散，乳头肿大变色，渗出褐色粘液样分泌物。全血细胞计数和血清化学指标均在正常范围内，未从分泌物培养物中分离出细菌，并且使用抗生素治疗无法消除临床症状。计算机断层扫描和血清催乳素水平支持了乳腺发育异常的诊断，这可能是由于分泌催乳素的垂体腺瘤所致。组织学评估证实存在垂体腺瘤，乳腺增生，不典型增生和囊性乳腺腺癌。免疫组织化学染色证实了垂体腺瘤中存在大量催乳激素分泌细胞。这是兔子体内泌乳素过多症伴乳腺发育不良的第二次报道，也是囊性乳腺腺癌与泌乳素分泌性垂体腺瘤相关的第一次报道。

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