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REALIS: Postgenomic Analysis ofListeria monocytogenes

机译:REALIS:单核细胞增生性李斯特菌的基因组分析

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Listeria monocytogenesis a remarkably successful food-borne pathogen. It is capable a) ofsurviving and proliferating under conditions that exist within the food chain, such as at lowtemperatures, high salt and low pH and b) of colonizing animal host tissues after ingestionof contaminated food, causing opportunistic infections mainly, but not exclusively, inimmunocompromised hosts. The ultimate goals of REALIS are two fold: Firstly, it aims tocompletely decipher all genes required for survival in and adaptation ofListeria monocytogenesto two very different environments, ie., the infected host and the externalenvironment. Secondly, using genomics and postgenomic tools, REALIS seeks to preciselyaddress fundamental questions regarding evolutionary relationships between pathogenicand non-pathogenic Listeria and to define qualities of particularly successful clonalpathovariants in causing disease. This project will provide both industry and health caremanagers with rational approaches to curbing food-borne contamination, minimising risksof infection and providing novel pharmacological approaches for halting the fulminantcourse of infection.
机译:单核细胞增生李斯特菌是一种非常成功的食源性病原体。它能够a)在食物链中存在的条件下生存和增殖,例如在低温,高盐和低pH下,以及b)摄入被污染的食物后定植在动物宿主组织中,引起机会性感染,主要但非排他性地是免疫受损主机。 REALIS的最终目标有两个:首先,它的目的是完全破译单核细胞增生性李斯特菌在两种不同环境中的生存和适应所需的所有基因,即被感染的宿主和外部环境。其次,REALIS使用基因组学和后基因组学工具,试图精确地解决有关病原性和非病原性李斯特菌之间进化关系的基本问题,并确定导致疾病的特别成功的克隆病原体的质量。该项目将为工业和卫生保健管理人员提供合理的方法,以遏制食源性污染,最大程度地降低感染风险,并提供新颖的药理方法,以制止感染的爆发。

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