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REALIS: Postgenomic analysis of Listeria monocytogenes

机译:REALIS:单核细胞增生李斯特菌的基因组分析

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摘要

Listeria monocytogenes is a remarkably successful food-borne pathogen. It is capable a) of surviving and proliferating under conditions that exist within the food chain, such as at low temperatures, high salt and low pH and b) of colonizing animal host tissues after ingestion of contaminated food, causing opportunistic infections mainly, but not exclusively, in immunocompromised hosts. The ultimate goals of REALIS are two fold: Firstly, it aims to completely decipher all genes required for survival in and adaptation of Listeria monocytogenes to two very different environments, ie., the infected host and the external environment. Secondly, using genomics postgeonomic tools, REALIS seeks to precisely address fundamental questions regarding evolutionary relationships between pathogenic and non-pathogenic Listeria and to define qualities of particularly successful clonal pathovariants in causing disease. This project will provide both industry and health care managers with rational approaches to curbing food-borne contamination, minimising risks of infection and providing novel pharmacological approaches for halting the fulminant course of infection.
机译:单核细胞增生李斯特菌是一种非常成功的食源性病原体。它能够a)在食物链中存在的条件下生存和增殖,例如在低温,高盐和低pH下,以及b)摄入被污染的食物后在动物宿主组织中定植,主要引起机会性感染,但不能仅在免疫受损的宿主中。 REALIS的最终目标有两个方面:首先,它的目的是完全破译单核细胞增生李斯特菌的生存和适应两种完全不同的环境(即感染的宿主和外部环境)所需的所有基因。其次,使用基因组学后基因组学工具,REARIS寻求精确解决有关致病性李斯特菌与非致病性李斯特菌之间进化关系的基本问题,并定义导致疾病的特别成功的克隆性致病变量的质量。该项目将为工业和卫生保健管理人员提供合理的方法,以减少食源性污染,最大程度地降低感染风险,并提供新颖的药理方法,以制止感染的爆发。

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