Transgenic Animal Technology: Alternatives in Genotyping and Phenotyping

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Transgenic Animal Technology: Alternatives in Genotyping and Phenotyping

机译：转基因动物技术：基因分型和表型分析的替代方法

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Overthepastdecade,breakthroughtechnologiesintransgenicanimaltechnologyandfunctionalgenomicshaveplayedacentralroleintheexplosivegrowthofrodentmodelingandinscientificinnovation.Variousnoninvasivealternativestoroutinesurgicalbiopsyhavebeendescribedforgenotypicandphenotypicanalysesoflaboratoryanimals.Anumberofoptionsareavailabletorefineorreplacepotentiallypainfulandinvasiveproceduresrangingfromtissuebiopsies(includingtailbiopsiesandtoedocking)toseveralbloodsamplingtechniques.Unfortunately,adoptionofmanynon-orminimallyinvasivealternativeshasprovendifficultonanumberoffrontsrangingfromhistoricalreservationstoproceduralexpectationsandactualexperimentalproductivity.Similarly,avarietyofphenotypingconsiderationshaveaddressedthroughputefficienciesandthehealthandwellbeingofresearchanimals.Fromananimalwelfareperspective,markedincreasesinlaboratoryanimalpopulationshaveaccompaniedrapidadvancementsspanningthelifesciences.Asdescribedforrodentmodeling,butwithapplicationsacrossmanylaboratoryanimalspecies,diverseproceduralrefinementsareavailablethatwillreadilyaidintheanalysisofwholeanimalmodels.Ultimately,non-invasivetechnologiesandcomplementaryrefinementshavebearingonthequalityandreproducibilityofdatathatarereported,aswellasofcriticalimportancetothewellbeingandethicalmanagementofanimalsatalldevelopmentalstages:fromfetalexistence,totheneonatalperiod,andonthroughadulthood.

机译：Overthepastdecade，breakthroughtechnologiesintransgenicanimaltechnologyandfunctionalgenomicshaveplayedacentralroleintheexplosivegrowthofrodentmodelingandinscientificinnovation.Variousnoninvasivealternativestoroutinesurgicalbiopsyhavebeendescribedforgenotypicandphenotypicanalysesoflaboratoryanimals.Anumberofoptionsareavailabletorefineorreplacepotentiallypainfulandinvasiveproceduresrangingfromtissuebiopsies（includingtailbiopsiesandtoedocking）toseveralbloodsamplingtechniques.Unfortunately，adoptionofmanynon-orminimallyinvasivealternativeshasprovendifficultonanumberoffrontsrangingfromhistoricalreservationstoproceduralexpectationsandactualexperimentalproductivity.Similarly，avarietyofphenotypingconsiderationshaveaddressedthroughputefficienciesandthehealthandwellbeingofresearchanimals.Fromananimalwelfareperspective，markedincreasesinlaboratoryanimalpopulationshaveaccompaniedrapidadvancementsspanningthelifesciences.Asdescribedforrodentmodeling，butwithapplicationsacrossmanylaboratoryanimalspecies，最终，非侵入性技术和互补性改进将对报告的数据的质量和可再现性产生全面的重视，并且整个动物的整个生命周期都将保持整个生命周期，直到整个生命周期，整个动物的整个生命周期都将变得如此重要。

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《Comparative Medicine》 |2003年第2期|共页
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Transgenic animal technology: Alternatives in genotyping and phenotyping [J] . Pinkert CA Comparative Medicine . 2003,第2期

机译：转基因动物技术：基因分型和表型选择
2. Computational strategies for alternative single-step Bayesian regression models with large numbers of genotyped and non-genotyped animals [J] . Rohan L. Fernando, Hao Cheng, Bruce L. Golden, Genetics, selection, evolution . 2016,第1期

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3. Are Allele Counts from NGS-Data a Better Alternative than Called Genotypes for Testing Phenotype-Genotype Associations? [J] . Silos Rosa Gonzalez, Bermejo Justo Lorenzo Human Heredity . 2016,第4期

机译：等位基因是否来自NGS-DATA的基于称为表型基因型关联的称为基因型的更好的替代品？
4. LOW INVASIVE METABOLOMIC PHENOTYPING: A POTENTIAL ALTERNATIVE FOR GENOTYPING OF GLIOMAS [C] . Paulina Zofia Gorynska, Krzysztof Gorynski, Kamila Chmara, International Mass Spectrometry Conference . 2018

机译：低侵入性代谢组分：胶质瘤的基因分型的潜在替代方案
5. Alternative methods to produce transgenic animals. [D] . Chan, Anthony Wing-Sang. 1997

机译：生产转基因动物的替代方法。
6. The prospects for recombinant proteins from transgenic animals: A few successes along with the advent of new technologies increase the allure of transgenic animals for the production of therapeutic human proteins [O] . Philip Hunter 2019

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7. Computational strategies for alternative single-step Bayesian regression models with large numbers of genotyped and non-genotyped animals [O] . 2016

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8. Framework for Validation and Implementation of In vitro Toxicity Tests: Report of the Validation and Technology Transfer Committee of the Johns Hopkins Center for Alternatives to Animal Testing [R] . Goldberg, A. M., Frazier, J. M., Brusick, D., 1993

机译：验证和实施体外毒性试验的框架：约翰霍普金斯动物试验替代中心验证和技术转让委员会的报告

Transgenic Animal Technology: Alternatives in Genotyping and Phenotyping

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