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The Influence of 3′UTRs on MicroRNA Function Inferred from Human SNP Data

机译：从人类SNP数据推断3'UTR对MicroRNA功能的影响

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MicroRNAs (miRNAs) regulate gene expression posttranscriptionally. Although previous efforts have demonstrated the functional importance of target sites on miRNAs, little is known about the influence of the rest of 3′ untranslated regions (3′UTRs) of target genes on microRNA function. We conducted a genome-wide study and found that the entire 3′UTR sequences could also play important roles on miRNA function in addition to miRNA target sites. This was evidenced by the fact that human single nucleotide polymorphisms (SNPs) on both seed target region and the rest of 3′UTRs of miRNA target genes were under significantly stronger negative selection, when compared to non-miRNA target genes. We also discovered that the flanking nucleotides on both sides of miRNA target sites were subject to moderate strong selection. A local sequence region of ~67 nucleotides with symmetric structure is herein defined. Additionally, from gene expression analysis, we found that SNPs and miRNA target sites on target sequences may interactively affect gene expression.
机译：MicroRNA（miRNA）转录后调节基因表达。尽管先前的努力已经证明了靶位点在miRNA上的功能重要性，但对于靶基因的其余3'非翻译区（3'UTR）对microRNA功能的影响知之甚少。我们进行了全基因组研究，发现除了miRNA靶位点外，整个3'UTR序列在miRNA功能上也起着重要作用。事实证明，与非miRNA靶基因相比，miRNA靶基因的种子靶区域和其余3'UTR上的人类单核苷酸多态性（SNP）都具有明显更强的阴性选择。我们还发现，miRNA目标位点两侧的侧翼核苷酸均受到中等强度的选择。本文定义了具有对称结构的〜67个核苷酸的局部序列区域。此外，从基因表达分析中，我们发现靶序列上的SNP和miRNA靶位点可能相互作用地影响基因表达。

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