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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Anticardiolipin Antibodies in Patients with Chronic Hepatitis C Virus Infection: Characterization in Relation to Antiphospholipid Syndrome
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Anticardiolipin Antibodies in Patients with Chronic Hepatitis C Virus Infection: Characterization in Relation to Antiphospholipid Syndrome

机译：慢性丙型肝炎病毒感染患者的抗心磷脂抗体：与抗磷脂综合征相关的表征

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The antiphospholipid syndrome (APS) is usually defined by the association of clinical manifestations that comprise venous and/or arterial thrombosis, recurrent fetal losses, and thrombocytopenia, along with the presence of anticardiolipin (aCL) antibodies and/or lupus anticoagulant. Various infectious diseases can induce aCL; however, these antibodies are not usually associated with thrombotic events, as happens with autoimmune diseases, in which these antibodies need the presence of β2-glycoprotein I. Levels of immunoglobulin G (IgG) and IgM aCL antibodies were determined by enzyme-linked immunosorbent assay for 243 patients with chronic hepatitis C virus (HCV) infection and 100 healthy controls. Clinical events of APS, the level of β2-glycoprotein dependence of aCL, the presence of cryoglobulins and other autoantibodies, and cross-reactivity between purified aCL and HCV were evaluated. Positive results for aCL antibodies were found more frequently (3.3%) for the patients with HCV infection than for healthy controls (0%). All positive aCL antibodies were β2-glycoprotein I independent. No significant association was found between aCL antibodies and clinical manifestations of APS, neither was one found between the presence of other autoantibodies or cryoglobulins and that of aCL. Finally, no cross-reactivity between aCL antibodies and HCV antigens was observed. As previously reported, aCL antibodies seem to be an epiphenomenon, and they do not have clinical or laboratory significance in HCV patients.
机译：抗磷脂综合症（APS）通常由临床表现的关联来定义，包括静脉和/或动脉血栓形成，复发性胎儿丢失和血小板减少以及抗心磷脂（aCL）抗体和/或狼疮抗凝剂的存在。各种传染病均可诱发aCL;但是，这些抗体通常不像自身免疫性疾病那样与血栓形成事件相关，在这些疾病中，这些抗体需要存在β 2 糖蛋白I。免疫球蛋白G（IgG）和IgM aCL抗体的水平通过酶联免疫吸附测定法测定了243例慢性丙型肝炎病毒（HCV）感染患者和100例健康对照者。评估了APS的临床事件，aCL的β 2 -糖蛋白依赖性水平，冷球蛋白和其他自身抗体的存在以及纯化的aCL和HCV之间的交叉反应性。 HCV感染患者的aCL抗体阳性结果（3.3％）比健康对照者（0％）更常见。所有阳性aCL抗体均独立于β 2 -糖蛋白I。在aCL抗体和APS的临床表现之间未发现显着关联，在其他自身抗体或冷球蛋白与aCL的存在之间也未发现任何关联。最后，未观察到aCL抗体与HCV抗原之间的交叉反应。如先前报道，aCL抗体似乎是一种现象，并且在HCV患者中没有临床或实验室意义。

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