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首页> 外文期刊>European journal of gastroenterology and hepatology >Anticardiolipin antibodies in chronic hepatitis B and chronic hepatitis D infection, and hepatitis B-related hepatocellular carcinoma. Relationship with portal vein thrombosis.
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Anticardiolipin antibodies in chronic hepatitis B and chronic hepatitis D infection, and hepatitis B-related hepatocellular carcinoma. Relationship with portal vein thrombosis.

机译：抗心磷脂抗体可治疗慢性乙型肝炎和慢性丙型肝炎，以及乙型肝炎相关的肝细胞癌。与门静脉血栓形成的关系。

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OBJECTIVE: To assess the presence of anticardiolipin antibodies (ACAs) in patients with chronic hepatitis B virus (HBV) infection, chronic hepatitis D virus (HDV) infection and HBV-related hepatocellular carcinoma (HCC) and to associate this with the incidence of portal vein thrombosis (PVT) in HCC patients. PATIENTS AND METHODS: Sixty-five cirrhotic patients with HBV-related HCC, 28 naive patients with chronic HBV infection and 14 naive patients with chronic HDV infection were enrolled prospectively in the study. Thirty-two healthy blood donors were used as controls. The ACAs (immunoglobulin G and immunoglobulin M) were measured using an enzyme-linked immunosorbent assay system. Statistical analysis used non-parametric methodology (chi-squared test, Student t-test and Fisher exact test, P value<0.05). RESULTS: Eleven of the 65 patients with HCC (16.9%) showed a positive ACA titre and 22 of the patients (34%) had PVT. Of these patients, eight (36%) had a positive ACA titre. In contrast, from the 43 patients without PVT, only three (11%) showed a positive titre. From the 28 HBV patients, six (21.5%) had a positive ACA titre, and six out of 14 (42.8%) HDV patients also showed a positive ACA titre. Three of the six ACA positive HBV patients presented an extrahepatic manifestation of the disease. One out of 32 control patients (3%) had positive ACAs. CONCLUSION: Both chronic HBV and chronic HDV infections are potent stimulants for the production of ACAs. The presence of ACAs in a great proportion of HBV-cirrhosis-related HCC patients with PVT suggests their possible participation in thrombotic mechanisms and in the hypercoagulable state that occurs in advanced liver disease and HCC.
机译：目的：评估慢性乙型肝炎病毒（HBV），慢性丙型肝炎病毒（HDV）感染和HBV相关肝细胞癌（HCC）患者中抗心磷脂抗体（ACA）的存在并将其与门脉发生率相关HCC患者的静脉血栓形成（PVT）。患者与方法：前瞻性纳入了65例HBV相关性HCC肝硬化患者，28例初次慢性HBV感染的初次患者和14例初次慢性HDV感染的初次患者。 32名健康献血者用作对照。使用酶联免疫吸附测定系统测量ACA（免疫球蛋白G和免疫球蛋白M）。统计分析使用非参数方法（卡方检验，Student t检验和Fisher精确检验，P值<0.05）。结果：65例HCC患者中11例（16.9％）的ACA滴度呈阳性，22例（34％）的患者进行了PVT。在这些患者中，八名（36％）的ACA滴度为阳性。相反，在没有PVT的43例患者中，只有3例（11％）显示出阳性滴度。在28例HBV患者中，有6名（21.5％）的ACA滴度为阳性，​​而在14名（42.8％）的HDV患者中也有6例的ACA滴度也为阳性。 6名ACA阳性HBV患者中有3名表现出该病的肝外表现。 32名对照患者中有1名（3％）的ACA阳性。结论：慢性HBV和慢性HDV感染都是产生ACA的有效刺激物。在大部分患有PVT的HBV肝硬化相关的HCC患者中，ACA的存在表明他们可能参与血栓形成机制和晚期肝病和HCC中发生的高凝状态。

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