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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Effect of Probiotic Bacteria on Induction and Maintenance of Oral Tolerance to β-Lactoglobulin in Gnotobiotic Mice
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Effect of Probiotic Bacteria on Induction and Maintenance of Oral Tolerance to β-Lactoglobulin in Gnotobiotic Mice

机译：益生菌对诱导型小鼠β-乳球蛋白耐受性的诱导和维持作用

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摘要

In this study, the effect of Lactobacillus paracasei (NCC 2461), Lactobacillus johnsonii (NCC 533) and Bifidobacterium lactis Bb12 (NCC 362) on the induction and maintenance of oral tolerance to bovine β-lactoglobulin (BLG) was investigated in mice. Germfree mice were monocolonized with one of the three strains before oral administration of whey protein to induce tolerance. Mice were then injected with BLG and sacrificed 28 or 50 days after whey protein feeding for humoral and cellular response measurement. Conventional and germfree mice were used as controls. Both humoral and cellular responses were better suppressed in conventional mice than in germfree and monoassociated mice throughout the experiment and better suppressed in L. paracasei-associated mice than in mice colonized with B. lactis or L. johnsonii. The latter two mono-associations suppressed humoral responses only partially and cellular responses not at all. This study provides evidence that probiotics modulate the oral tolerance response to BLG in mice. The mono-colonization effect is strain-dependant, the best result having been obtained with L. paracasei.
机译：在这项研究中，副干酪乳杆菌（NCC 2461），约翰逊乳杆菌（NCC 533）和乳酸双歧杆菌 Bb12（NCC 362）研究了小鼠对牛β-乳球蛋白（BLG）的口服耐受性的诱导和维持。在口服给予乳清蛋白以诱导耐受之前，将无毒小鼠与三种品系之一进行单菌落化。然后给小鼠注射BLG，并在喂入乳清蛋白28或50天后处死，用于体液和细胞反应测量。常规的和无菌的小鼠用作对照。在整个实验过程中，常规小鼠的体液和细胞应答均优于无菌和单联小鼠，而在 L中则更好。与Paracasei 相关的小鼠比定植在 B中的小鼠要高。乳酸或 L。约翰逊氏菌。后两个单一联想仅部分抑制体液反应，而根本不抑制细胞反应。这项研究提供的证据表明，益生菌可以调节小鼠对BLG的口服耐受性。单菌落效应取决于菌株， L可获得最佳结果。 paracasei 。

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